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Phase II Study of Dabrafenib and Trametinib in Patients With Tumors With BRAFV600E Mutations: Updated Results From NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol H.

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Title: Phase II Study of Dabrafenib and Trametinib in Patients With Tumors With BRAFV600E Mutations: Updated Results From NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol H.
Authors: Salama AKS; Duke University, Durham, NC., Wang V; Dana Farber Cancer Institute-ECOG-ACRIN Biostatistical Center, Boston, MA., Macrae ER; Columbus Oncology and Hematology Associates, Columbus, OH., Park JI; Medical College of Wisconsin, Milwaukee, WI., Chen HX; Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD., Gray RJ; Dana Farber Cancer Institute-ECOG-ACRIN Biostatistical Center, Boston, MA., McShane LM; Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD., Rubinstein LV; Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD., Patton D; Center for Biomedical Informatics and Information Technology, National Cancer Institute, Bethesda, MD., Williams PM; Frederick National Laboratory for Cancer Research, Frederick, MD., Hamilton SR; City of Hope National Medical Center and Comprehensive Cancer Center, Duarte, CA., Armstrong DK; Johns Hopkins University, Baltimore, MD., Tricoli JV; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD., Conley BA; Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD., Arteaga CL; University of Texas Southwestern Medical Center, Dallas, TX., Harris LN; Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD., O'Dwyer PJ; University of Pennsylvania, Philadelphia, PA., Chen AP; Division of Cancer Treatment and Diagnosis, Developmental Therapeutics Clinic, NCI, Bethesda, MD., Flaherty KT; Massachusetts General Hospital Cancer Center, Boston, MA.
Source: JCO precision oncology [JCO Precis Oncol] 2026 Jan; Vol. 10, pp. e2500338. Date of Electronic Publication: 2026 Jan 14.
Publication Type: Journal Article; Clinical Trial, Phase II
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 101705370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2473-4284 (Electronic) Linking ISSN: 24734284 NLM ISO Abbreviation: JCO Precis Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phase II Study of Dabrafenib and Trametinib in Patients With Tumors With BRAF<superscript>V600E</superscript> Mutations: Updated Results From NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol H.
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  Data: <searchLink fieldCode="AU" term="%22Salama+AKS%22">Salama AKS</searchLink>; Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Wang+V%22">Wang V</searchLink>; Dana Farber Cancer Institute-ECOG-ACRIN Biostatistical Center, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Macrae+ER%22">Macrae ER</searchLink>; Columbus Oncology and Hematology Associates, Columbus, OH.<br /><searchLink fieldCode="AU" term="%22Park+JI%22">Park JI</searchLink>; Medical College of Wisconsin, Milwaukee, WI.<br /><searchLink fieldCode="AU" term="%22Chen+HX%22">Chen HX</searchLink>; Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22Gray+RJ%22">Gray RJ</searchLink>; Dana Farber Cancer Institute-ECOG-ACRIN Biostatistical Center, Boston, MA.<br /><searchLink fieldCode="AU" term="%22McShane+LM%22">McShane LM</searchLink>; Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22Rubinstein+LV%22">Rubinstein LV</searchLink>; Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22Patton+D%22">Patton D</searchLink>; Center for Biomedical Informatics and Information Technology, National Cancer Institute, Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22Williams+PM%22">Williams PM</searchLink>; Frederick National Laboratory for Cancer Research, Frederick, MD.<br /><searchLink fieldCode="AU" term="%22Hamilton+SR%22">Hamilton SR</searchLink>; City of Hope National Medical Center and Comprehensive Cancer Center, Duarte, CA.<br /><searchLink fieldCode="AU" term="%22Armstrong+DK%22">Armstrong DK</searchLink>; Johns Hopkins University, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Tricoli+JV%22">Tricoli JV</searchLink>; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22Conley+BA%22">Conley BA</searchLink>; Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22Arteaga+CL%22">Arteaga CL</searchLink>; University of Texas Southwestern Medical Center, Dallas, TX.<br /><searchLink fieldCode="AU" term="%22Harris+LN%22">Harris LN</searchLink>; Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22O'Dwyer+PJ%22">O'Dwyer PJ</searchLink>; University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Chen+AP%22">Chen AP</searchLink>; Division of Cancer Treatment and Diagnosis, Developmental Therapeutics Clinic, NCI, Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22Flaherty+KT%22">Flaherty KT</searchLink>; Massachusetts General Hospital Cancer Center, Boston, MA.
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  Data: <searchLink fieldCode="JN" term="%22101705370%22">JCO precision oncology</searchLink> [JCO Precis Oncol] 2026 Jan; Vol. 10, pp. e2500338. <i>Date of Electronic Publication: </i>2026 Jan 14.
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  Data: Journal Article; Clinical Trial, Phase II
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+of+Clinical+Oncology%22">American Society of Clinical Oncology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101705370 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2473-4284 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2224734284%22">24734284 </searchLink><i>NLM ISO Abbreviation: </i>JCO Precis Oncol <i>Subsets: </i>MEDLINE
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        Value: 10.1200/PO-25-00338
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              Text: 2026 Jan
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