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3D culture reveals dual role of ICAM-1 in mediating tissue-specific human MSC spheroid formation & enhanced immunomodulation.

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Title: 3D culture reveals dual role of ICAM-1 in mediating tissue-specific human MSC spheroid formation & enhanced immunomodulation.
Authors: Wang LT; School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University (TMU), Taipei, Taiwan; Ph.D. Program in Medical Biotechnology, College of Medical Science and Technology, TMU, Taipei, Taiwan., Wang HH; Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan., Doan DTT; School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University (TMU), Taipei, Taiwan., Lin YF; School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University (TMU), Taipei, Taiwan., Liao CY; Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan., Hsu PJ; Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan., Chang CC; Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan., Yen ML; Department of Obstetrics & Gynecology, National Taiwan University (NTU) Hospital & College of Medicine, NTU, Taipei, Taiwan., Liu KJ; National Institute of Cancer Research, NHRI, Tainan, Taiwan., Sytwu HK; National Institute of Infectious Diseases & Vaccinology, NHRI, Zhunan, Taiwan; Graduate Institute of Microbiology & Immunology, National Defense Medical Center, Taipei, Taiwan., Yen BL; Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan. Electronic address: blyen@nhri.edu.tw.
Source: Biomaterials [Biomaterials] 2026 Jul; Vol. 330, pp. 123998. Date of Electronic Publication: 2026 Jan 09.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: 3D culture reveals dual role of ICAM-1 in mediating tissue-specific human MSC spheroid formation & enhanced immunomodulation.
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  Data: <searchLink fieldCode="AU" term="%22Wang+LT%22">Wang LT</searchLink>; School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University (TMU), Taipei, Taiwan; Ph.D. Program in Medical Biotechnology, College of Medical Science and Technology, TMU, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+HH%22">Wang HH</searchLink>; Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Doan+DTT%22">Doan DTT</searchLink>; School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University (TMU), Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YF%22">Lin YF</searchLink>; School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University (TMU), Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liao+CY%22">Liao CY</searchLink>; Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+PJ%22">Hsu PJ</searchLink>; Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+CC%22">Chang CC</searchLink>; Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yen+ML%22">Yen ML</searchLink>; Department of Obstetrics & Gynecology, National Taiwan University (NTU) Hospital & College of Medicine, NTU, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+KJ%22">Liu KJ</searchLink>; National Institute of Cancer Research, NHRI, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sytwu+HK%22">Sytwu HK</searchLink>; National Institute of Infectious Diseases & Vaccinology, NHRI, Zhunan, Taiwan; Graduate Institute of Microbiology & Immunology, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yen+BL%22">Yen BL</searchLink>; Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan. Electronic address: blyen@nhri.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%228100316%22">Biomaterials</searchLink> [Biomaterials] 2026 Jul; Vol. 330, pp. 123998. <i>Date of Electronic Publication: </i>2026 Jan 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8100316 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-5905 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201429612%22">01429612 </searchLink><i>NLM ISO Abbreviation: </i>Biomaterials <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.biomaterials.2026.123998
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              Text: 2026 Jul
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