Osimertinib and Stereotactic Radiosurgery for Brain Metastases in EGFR-Mutated Lung Cancer: The STARLET Joint Analysis of OUTRUN and LUOSICNS Randomized Trials.
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| Title: | Osimertinib and Stereotactic Radiosurgery for Brain Metastases in EGFR-Mutated Lung Cancer: The STARLET Joint Analysis of OUTRUN and LUOSICNS Randomized Trials. |
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| Authors: | Lee CK; Department of Medical Oncology, Cancer Care Centre, St. George Hospital, Kogarah, New South Wales, Australia; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, New South Wales, Australia., Lefresne S; Department of Radiation Oncology, BC Cancer - Vancouver, Vancouver, British Columbia, Canada; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Soon YY; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, New South Wales, Australia; Department of Radiation Oncology, National University Cancer Institute, Singapore, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Electronic address: mdcsoon@nus.edu.sg., Robledo K; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, New South Wales, Australia., Nichol A; Department of Radiation Oncology, BC Cancer - Vancouver, Vancouver, British Columbia, Canada; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Sahgal A; Department of Radiation Oncology, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Pinkham MB; Department of Radiation Oncology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia., Melosky B; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medical Oncology, BC Cancer - Vancouver, Vancouver, British Columbia, Canada., Huang Y; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore, Singapore., McDermott R; Department of Radiation Oncology, BC Cancer - Vancouver, Vancouver, British Columbia, Canada; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Department of Radiation Oncology, University Hospital Galway, Galway, United Kingdom; School of Medicine, University of Galway, Galway, United Kingdom., Tham IWK; Radiation Oncology Centre, Mount Elizabeth Novena Hospital, Singapore, Singapore., Parmar A; Department of Medical Oncology, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Tey JCS; Department of Radiation Oncology, National University Cancer Institute, Singapore, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Liu M; Department of Radiation Oncology, BC Cancer - Vancouver, Vancouver, British Columbia, Canada; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Solomon BJ; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, Australia., Sacher A; Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada., Leong CN; Department of Radiation Oncology, National University Cancer Institute, Singapore, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Laskin J; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medical Oncology, BC Cancer - Vancouver, Vancouver, British Columbia, Canada., Koh WY; Department of Radiation Oncology, National University Cancer Institute, Singapore, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Menjak IB; Department of Medical Oncology, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Ang Y; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore, Singapore., Shultz DB; Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada., Low JL; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore, Singapore., Doherty M; Department of Medical Oncology, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Cancer Centre of Care, St. Vincent's Private Hospital, Elm Park, Dublin, United Kingdom., Yong C; Department of Diagnostic Imaging, National University Hospital Singapore, Singapore, Singapore., Lim MC; Department of Diagnostic Imaging, National University Hospital Singapore, Singapore, Singapore., Tan AP; Department of Diagnostic Imaging, National University Hospital Singapore, Singapore, Singapore; Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Translational Neuroscience Program, Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research, Singapore, Singapore., Soo RA; Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore, Singapore., Hegi-Johnson F; Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, Australia., Ho C; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medical Oncology, BC Cancer - Vancouver, Vancouver, British Columbia, Canada. |
| Source: | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2026 May; Vol. 21 (5), pp. 103549. Date of Electronic Publication: 2026 Jan 12. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 101274235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-1380 (Electronic) Linking ISSN: 15560864 NLM ISO Abbreviation: J Thorac Oncol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41534788 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Osimertinib and Stereotactic Radiosurgery for Brain Metastases in EGFR-Mutated Lung Cancer: The STARLET Joint Analysis of OUTRUN and LUOSICNS Randomized Trials. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Lee+CK%22">Lee CK</searchLink>; Department of Medical Oncology, Cancer Care Centre, St. George Hospital, Kogarah, New South Wales, Australia; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Lefresne+S%22">Lefresne S</searchLink>; Department of Radiation Oncology, BC Cancer - Vancouver, Vancouver, British Columbia, Canada; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Soon+YY%22">Soon YY</searchLink>; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, New South Wales, Australia; Department of Radiation Oncology, National University Cancer Institute, Singapore, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Electronic address: mdcsoon@nus.edu.sg.<br /><searchLink fieldCode="AU" term="%22Robledo+K%22">Robledo K</searchLink>; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Nichol+A%22">Nichol A</searchLink>; Department of Radiation Oncology, BC Cancer - Vancouver, Vancouver, British Columbia, Canada; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Sahgal+A%22">Sahgal A</searchLink>; Department of Radiation Oncology, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Pinkham+MB%22">Pinkham MB</searchLink>; Department of Radiation Oncology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Melosky+B%22">Melosky B</searchLink>; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medical Oncology, BC Cancer - Vancouver, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22McDermott+R%22">McDermott R</searchLink>; Department of Radiation Oncology, BC Cancer - Vancouver, Vancouver, British Columbia, Canada; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Department of Radiation Oncology, University Hospital Galway, Galway, United Kingdom; School of Medicine, University of Galway, Galway, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tham+IWK%22">Tham IWK</searchLink>; Radiation Oncology Centre, Mount Elizabeth Novena Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Parmar+A%22">Parmar A</searchLink>; Department of Medical Oncology, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Tey+JCS%22">Tey JCS</searchLink>; Department of Radiation Oncology, National University Cancer Institute, Singapore, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Department of Radiation Oncology, BC Cancer - Vancouver, Vancouver, British Columbia, Canada; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Solomon+BJ%22">Solomon BJ</searchLink>; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Sacher+A%22">Sacher A</searchLink>; Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Leong+CN%22">Leong CN</searchLink>; Department of Radiation Oncology, National University Cancer Institute, Singapore, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Laskin+J%22">Laskin J</searchLink>; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medical Oncology, BC Cancer - Vancouver, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Koh+WY%22">Koh WY</searchLink>; Department of Radiation Oncology, National University Cancer Institute, Singapore, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Menjak+IB%22">Menjak IB</searchLink>; Department of Medical Oncology, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ang+Y%22">Ang Y</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Shultz+DB%22">Shultz DB</searchLink>; Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Low+JL%22">Low JL</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Doherty+M%22">Doherty M</searchLink>; Department of Medical Oncology, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Cancer Centre of Care, St. Vincent's Private Hospital, Elm Park, Dublin, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Yong+C%22">Yong C</searchLink>; Department of Diagnostic Imaging, National University Hospital Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+MC%22">Lim MC</searchLink>; Department of Diagnostic Imaging, National University Hospital Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+AP%22">Tan AP</searchLink>; Department of Diagnostic Imaging, National University Hospital Singapore, Singapore, Singapore; Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Translational Neuroscience Program, Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Soo+RA%22">Soo RA</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Hegi-Johnson+F%22">Hegi-Johnson F</searchLink>; Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ho+C%22">Ho C</searchLink>; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medical Oncology, BC Cancer - Vancouver, Vancouver, British Columbia, Canada. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101274235%22">Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer</searchLink> [J Thorac Oncol] 2026 May; Vol. 21 (5), pp. 103549. <i>Date of Electronic Publication: </i>2026 Jan 12. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101274235 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1556-1380 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215560864%22">15560864 </searchLink><i>NLM ISO Abbreviation: </i>J Thorac Oncol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41534788 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.jtho.2026.01.001 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 103549 Titles: – TitleFull: Osimertinib and Stereotactic Radiosurgery for Brain Metastases in EGFR-Mutated Lung Cancer: The STARLET Joint Analysis of OUTRUN and LUOSICNS Randomized Trials. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lee CK – PersonEntity: Name: NameFull: Lefresne S – PersonEntity: Name: NameFull: Soon YY – PersonEntity: Name: NameFull: Robledo K – PersonEntity: Name: NameFull: Nichol A – PersonEntity: Name: NameFull: Sahgal A – PersonEntity: Name: NameFull: Pinkham MB – PersonEntity: Name: NameFull: Melosky B – PersonEntity: Name: NameFull: Huang Y – PersonEntity: Name: NameFull: McDermott R – PersonEntity: Name: NameFull: Tham IWK – PersonEntity: Name: NameFull: Parmar A – PersonEntity: Name: NameFull: Tey JCS – PersonEntity: Name: NameFull: Liu M – PersonEntity: Name: NameFull: Solomon BJ – PersonEntity: Name: NameFull: Sacher A – PersonEntity: Name: NameFull: Leong CN – PersonEntity: Name: NameFull: Laskin J – PersonEntity: Name: NameFull: Koh WY – PersonEntity: Name: NameFull: Menjak IB – PersonEntity: Name: NameFull: Ang Y – PersonEntity: Name: NameFull: Shultz DB – PersonEntity: Name: NameFull: Low JL – PersonEntity: Name: NameFull: Doherty M – PersonEntity: Name: NameFull: Yong C – PersonEntity: Name: NameFull: Lim MC – PersonEntity: Name: NameFull: Tan AP – PersonEntity: Name: NameFull: Soo RA – PersonEntity: Name: NameFull: Hegi-Johnson F – PersonEntity: Name: NameFull: Ho C IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2026 May Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1556-1380 Numbering: – Type: volume Value: 21 – Type: issue Value: 5 Titles: – TitleFull: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer Type: main |
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