EGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independent KEAP1 oligomerizing molecular bridge.

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Title: EGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independent KEAP1 oligomerizing molecular bridge.
Authors: Bassil CF; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Dillon K; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Anderson GR; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Mayro B; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Askin KN; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Winter PS; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Harry S; Krantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA., Gruber S; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Hall TM; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Hoj JP; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Cerda-Smith C; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Hutchinson HM; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Killarney ST; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Heffernan A; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Teddy C; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Singleton KR; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Qin L; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Jubien-Girard K; Institut de Chimie de Nice UMR-CNRS 7272, Université Nice Sophia Antipolis, Nice, France., Favreau C; Mediterranean Center for Molecular Medicine (C3M), Université Côte d'Azur, Nice, France., Robert G; Mediterranean Center for Molecular Medicine (C3M), Université Côte d'Azur, Nice, France., Tivon B; Department of Chemical and Structural Biology, The Weizmann Institute of Science, Rehovot, Israel., Livnah E; Department of Chemical and Structural Biology, The Weizmann Institute of Science, Rehovot, Israel., London N; Department of Chemical and Structural Biology, The Weizmann Institute of Science, Rehovot, Israel., Benhida R; Institut de Chimie de Nice UMR-CNRS 7272, Université Nice Sophia Antipolis, Nice, France.; Chemical & Biochemical Sciences Green-Process Engineering (CBS), Mohammed VI Polytechnic University, Benguerir, Morocco., Auberger P; Mediterranean Center for Molecular Medicine (C3M), Université Côte d'Azur, Nice, France., Pendergast AM; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Bar-Peled L; Krantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA., Lonard DM; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Martin AR; Institut de Chimie de Nice UMR-CNRS 7272, Université Nice Sophia Antipolis, Nice, France.; IBMM, University of Montpellier, CNRS ENSCM, Montpellier, France., Puissant A; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France., Wood KC; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA. kris.wood@duke.edu.
Source: Nature communications [Nat Commun] 2026 Jan 14; Vol. 17 (1), pp. 1726. Date of Electronic Publication: 2026 Jan 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-68424-1