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EGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independent KEAP1 oligomerizing molecular bridge.

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Title: EGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independent KEAP1 oligomerizing molecular bridge.
Authors: Bassil CF; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Dillon K; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Anderson GR; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Mayro B; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Askin KN; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Winter PS; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Harry S; Krantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA., Gruber S; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Hall TM; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Hoj JP; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Cerda-Smith C; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Hutchinson HM; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Killarney ST; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Heffernan A; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Teddy C; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Singleton KR; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Qin L; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Jubien-Girard K; Institut de Chimie de Nice UMR-CNRS 7272, Université Nice Sophia Antipolis, Nice, France., Favreau C; Mediterranean Center for Molecular Medicine (C3M), Université Côte d'Azur, Nice, France., Robert G; Mediterranean Center for Molecular Medicine (C3M), Université Côte d'Azur, Nice, France., Tivon B; Department of Chemical and Structural Biology, The Weizmann Institute of Science, Rehovot, Israel., Livnah E; Department of Chemical and Structural Biology, The Weizmann Institute of Science, Rehovot, Israel., London N; Department of Chemical and Structural Biology, The Weizmann Institute of Science, Rehovot, Israel., Benhida R; Institut de Chimie de Nice UMR-CNRS 7272, Université Nice Sophia Antipolis, Nice, France.; Chemical & Biochemical Sciences Green-Process Engineering (CBS), Mohammed VI Polytechnic University, Benguerir, Morocco., Auberger P; Mediterranean Center for Molecular Medicine (C3M), Université Côte d'Azur, Nice, France., Pendergast AM; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Bar-Peled L; Krantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA., Lonard DM; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Martin AR; Institut de Chimie de Nice UMR-CNRS 7272, Université Nice Sophia Antipolis, Nice, France.; IBMM, University of Montpellier, CNRS ENSCM, Montpellier, France., Puissant A; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France., Wood KC; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA. kris.wood@duke.edu.
Source: Nature communications [Nat Commun] 2026 Jan 14; Vol. 17 (1), pp. 1726. Date of Electronic Publication: 2026 Jan 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: EGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independent KEAP1 oligomerizing molecular bridge.
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  Data: <searchLink fieldCode="AU" term="%22Bassil+CF%22">Bassil CF</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Dillon+K%22">Dillon K</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+GR%22">Anderson GR</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Mayro+B%22">Mayro B</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Askin+KN%22">Askin KN</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Winter+PS%22">Winter PS</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Harry+S%22">Harry S</searchLink>; Krantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gruber+S%22">Gruber S</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Hall+TM%22">Hall TM</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Hoj+JP%22">Hoj JP</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Cerda-Smith+C%22">Cerda-Smith C</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Hutchinson+HM%22">Hutchinson HM</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Killarney+ST%22">Killarney ST</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Heffernan+A%22">Heffernan A</searchLink>; 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Department of Chemical and Structural Biology, The Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Livnah+E%22">Livnah E</searchLink>; Department of Chemical and Structural Biology, The Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22London+N%22">London N</searchLink>; Department of Chemical and Structural Biology, The Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Benhida+R%22">Benhida R</searchLink>; Institut de Chimie de Nice UMR-CNRS 7272, Université Nice Sophia Antipolis, Nice, France.; Chemical & Biochemical Sciences Green-Process Engineering (CBS), Mohammed VI Polytechnic University, Benguerir, Morocco.<br /><searchLink fieldCode="AU" term="%22Auberger+P%22">Auberger P</searchLink>; Mediterranean Center for Molecular Medicine (C3M), Université Côte d'Azur, Nice, France.<br /><searchLink fieldCode="AU" term="%22Pendergast+AM%22">Pendergast AM</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Bar-Peled+L%22">Bar-Peled L</searchLink>; Krantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lonard+DM%22">Lonard DM</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Martin+AR%22">Martin AR</searchLink>; Institut de Chimie de Nice UMR-CNRS 7272, Université Nice Sophia Antipolis, Nice, France.; IBMM, University of Montpellier, CNRS ENSCM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Puissant+A%22">Puissant A</searchLink>; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Wood+KC%22">Wood KC</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA. kris.wood@duke.edu.
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