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A novel synbiotic (SCM06) for anxiety and sensory hyperresponsiveness in children with autism spectrum disorder: an open-label pilot study.

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Title: A novel synbiotic (SCM06) for anxiety and sensory hyperresponsiveness in children with autism spectrum disorder: an open-label pilot study.
Authors: Wong OWH; Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR, China.; The D. H. Chen Foundation Hub of Advanced Technology for Child Health (HATCH), The Chinese University of Hong Kong, Hong Kong SAR, China., Xu Z; Microbiota I-Center (MagIC), Hong Kong SAR, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China., Chan SSM; Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR, China.; The D. H. Chen Foundation Hub of Advanced Technology for Child Health (HATCH), The Chinese University of Hong Kong, Hong Kong SAR, China., Mo FYM; Department of Psychiatry, Alice Ho Miu Ling Nethersole Hospital, Hong Kong SAR, China., Shea CKS; Department of Psychiatry, Alice Ho Miu Ling Nethersole Hospital, Hong Kong SAR, China., Su Q; Microbiota I-Center (MagIC), Hong Kong SAR, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China., Wan MYT; Microbiota I-Center (MagIC), Hong Kong SAR, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China., Cheung CP; Microbiota I-Center (MagIC), Hong Kong SAR, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China., Ching JYL; Microbiota I-Center (MagIC), Hong Kong SAR, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China., Tang W; Microbiota I-Center (MagIC), Hong Kong SAR, China., Tun HM; Microbiota I-Center (MagIC), Hong Kong SAR, China.; The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China., Chan FKL; The D. H. Chen Foundation Hub of Advanced Technology for Child Health (HATCH), The Chinese University of Hong Kong, Hong Kong SAR, China.; Microbiota I-Center (MagIC), Hong Kong SAR, China.; Centre for Gut Microbiota Research, The Chinese University of Hong Kong, Hong Kong SAR, China.; Li Ka Shing Institute of Health Sciences, State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China., Ng SC; Microbiota I-Center (MagIC), Hong Kong SAR, China. siewchienng@cuhk.edu.hk.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China. siewchienng@cuhk.edu.hk.; Li Ka Shing Institute of Health Sciences, State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China. siewchienng@cuhk.edu.hk.; New Cornerstone Science Laboratory, The Chinese University of Hong Kong, Hong Kong, China. siewchienng@cuhk.edu.hk.
Source: NPJ biofilms and microbiomes [NPJ Biofilms Microbiomes] 2026 Jan 14; Vol. 12 (1), pp. 36. Date of Electronic Publication: 2026 Jan 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101666944 Publication Model: Electronic Cited Medium: Internet ISSN: 2055-5008 (Electronic) Linking ISSN: 20555008 NLM ISO Abbreviation: NPJ Biofilms Microbiomes Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A novel synbiotic (SCM06) for anxiety and sensory hyperresponsiveness in children with autism spectrum disorder: an open-label pilot study.
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  Data: <searchLink fieldCode="AU" term="%22Wong+OWH%22">Wong OWH</searchLink>; Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR, China.; The D. H. Chen Foundation Hub of Advanced Technology for Child Health (HATCH), The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; Microbiota I-Center (MagIC), Hong Kong SAR, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Chan+SSM%22">Chan SSM</searchLink>; Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR, China.; The D. H. Chen Foundation Hub of Advanced Technology for Child Health (HATCH), The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Mo+FYM%22">Mo FYM</searchLink>; Department of Psychiatry, Alice Ho Miu Ling Nethersole Hospital, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Shea+CKS%22">Shea CKS</searchLink>; Department of Psychiatry, Alice Ho Miu Ling Nethersole Hospital, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Su+Q%22">Su Q</searchLink>; Microbiota I-Center (MagIC), Hong Kong SAR, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Wan+MYT%22">Wan MYT</searchLink>; Microbiota I-Center (MagIC), Hong Kong SAR, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Cheung+CP%22">Cheung CP</searchLink>; Microbiota I-Center (MagIC), Hong Kong SAR, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Ching+JYL%22">Ching JYL</searchLink>; Microbiota I-Center (MagIC), Hong Kong SAR, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Tang+W%22">Tang W</searchLink>; Microbiota I-Center (MagIC), Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Tun+HM%22">Tun HM</searchLink>; Microbiota I-Center (MagIC), Hong Kong SAR, China.; The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Chan+FKL%22">Chan FKL</searchLink>; The D. H. Chen Foundation Hub of Advanced Technology for Child Health (HATCH), The Chinese University of Hong Kong, Hong Kong SAR, China.; Microbiota I-Center (MagIC), Hong Kong SAR, China.; Centre for Gut Microbiota Research, The Chinese University of Hong Kong, Hong Kong SAR, China.; Li Ka Shing Institute of Health Sciences, State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Ng+SC%22">Ng SC</searchLink>; Microbiota I-Center (MagIC), Hong Kong SAR, China. siewchienng@cuhk.edu.hk.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China. siewchienng@cuhk.edu.hk.; Li Ka Shing Institute of Health Sciences, State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China. siewchienng@cuhk.edu.hk.; New Cornerstone Science Laboratory, The Chinese University of Hong Kong, Hong Kong, China. siewchienng@cuhk.edu.hk.
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        Value: 10.1038/s41522-025-00902-8
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        Text: English
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        StartPage: 36
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      – TitleFull: A novel synbiotic (SCM06) for anxiety and sensory hyperresponsiveness in children with autism spectrum disorder: an open-label pilot study.
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              Text: 2026 Jan 14
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