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A nowhere-to-hide mechanism ensures complete piRNA-directed DNA methylation.

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Title: A nowhere-to-hide mechanism ensures complete piRNA-directed DNA methylation.
Authors: Chowdhury T; Centre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK., Boyle S; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Zoch A; Centre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Xiang X; Centre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.; Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, International Campus, Zhejiang University, Haining, China., Mirandela MD; Centre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK., Fieler H; Centre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK., Spanos C; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK., Zou J; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK., Kelly D; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK., Bickmore WA; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Cook AG; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK., O'Carroll D; Centre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK. donal.ocarroll@ed.ac.uk.; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK. donal.ocarroll@ed.ac.uk.
Source: Nature [Nature] 2026 Feb; Vol. 650 (8102), pp. 779-785. Date of Electronic Publication: 2026 Jan 14.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Chowdhury+T%22">Chowdhury T</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Boyle+S%22">Boyle S</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Zoch+A%22">Zoch A</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Xiang+X%22">Xiang X</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.; Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, International Campus, Zhejiang University, Haining, China.<br /><searchLink fieldCode="AU" term="%22Mirandela+MD%22">Mirandela MD</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Fieler+H%22">Fieler H</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Spanos+C%22">Spanos C</searchLink>; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Zou+J%22">Zou J</searchLink>; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Kelly+D%22">Kelly D</searchLink>; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Bickmore+WA%22">Bickmore WA</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Cook+AG%22">Cook AG</searchLink>; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22O'Carroll+D%22">O'Carroll D</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK. donal.ocarroll@ed.ac.uk.; Centre for Cell Biology, University of Edinburgh, Edinburgh, UK. donal.ocarroll@ed.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2026 Feb; Vol. 650 (8102), pp. 779-785. <i>Date of Electronic Publication: </i>2026 Jan 14.
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