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Breathing lung-on-chip: a versatile tool for assessing respiratory toxicity across multiple therapeutic modalities.

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Title: Breathing lung-on-chip: a versatile tool for assessing respiratory toxicity across multiple therapeutic modalities.
Authors: Johansson L; Biopharma Safety, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.; Department of Immunotechnology, Lund University, Lund, Sweden., Raggi G; AlveoliX AG, Swiss Organs-on-Chip Innovation, Bern, Switzerland., Cartwright J; Pathology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Lindqvist J; Integrated Bioanalysis, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Froment L; AlveoliX AG, Swiss Organs-on-Chip Innovation, Bern, Switzerland., Andersson P; Safety Innovation, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Betts C; Immune Safety, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Hornberg JJ; Safety Sciences, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Hobi N; AlveoliX AG, Swiss Organs-on-Chip Innovation, Bern, Switzerland., Ollerstam A; Biopharma Safety, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Fitzpatrick P; Biopharma Safety, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. paul.fitzpatrick2@astrazeneca.com.
Source: Archives of toxicology [Arch Toxicol] 2026 Apr; Vol. 100 (4), pp. 1465-1484. Date of Electronic Publication: 2026 Jan 14.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Breathing lung-on-chip: a versatile tool for assessing respiratory toxicity across multiple therapeutic modalities.
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  Data: <searchLink fieldCode="AU" term="%22Johansson+L%22">Johansson L</searchLink>; Biopharma Safety, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.; Department of Immunotechnology, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Raggi+G%22">Raggi G</searchLink>; AlveoliX AG, Swiss Organs-on-Chip Innovation, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cartwright+J%22">Cartwright J</searchLink>; Pathology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lindqvist+J%22">Lindqvist J</searchLink>; Integrated Bioanalysis, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Froment+L%22">Froment L</searchLink>; AlveoliX AG, Swiss Organs-on-Chip Innovation, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Andersson+P%22">Andersson P</searchLink>; Safety Innovation, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Betts+C%22">Betts C</searchLink>; Immune Safety, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Hornberg+JJ%22">Hornberg JJ</searchLink>; Safety Sciences, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Hobi+N%22">Hobi N</searchLink>; AlveoliX AG, Swiss Organs-on-Chip Innovation, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ollerstam+A%22">Ollerstam A</searchLink>; Biopharma Safety, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Fitzpatrick+P%22">Fitzpatrick P</searchLink>; Biopharma Safety, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. paul.fitzpatrick2@astrazeneca.com.
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  Data: <searchLink fieldCode="JN" term="%220417615%22">Archives of toxicology</searchLink> [Arch Toxicol] 2026 Apr; Vol. 100 (4), pp. 1465-1484. <i>Date of Electronic Publication: </i>2026 Jan 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0417615 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0738 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203405761%22">03405761 </searchLink><i>NLM ISO Abbreviation: </i>Arch Toxicol <i>Subsets: </i>MEDLINE
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              Text: 2026 Apr
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