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Whole-Body Dynamic PET Imaging of Half-Life Extended Variable Domains of Heavy Chain-Only Antibodies: Beyond Blood Pharmacokinetics.

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Title: Whole-Body Dynamic PET Imaging of Half-Life Extended Variable Domains of Heavy Chain-Only Antibodies: Beyond Blood Pharmacokinetics.
Authors: Marchal E; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France., Goutal S; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France., Richard M; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France., N'Diaye ER; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France., Kuhnast B; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France., Truillet C; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France., Chevaleyre C; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France., Hinnen F; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France., Lemaitre J; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-Immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT/UMR-S 1184), 92265 Fontenay-aux-Roses, France., Relouzat F; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-Immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT/UMR-S 1184), 92265 Fontenay-aux-Roses, France., Van Bogaert T; Sanofi R&D, Technologiepark 21, 9052 Zwijnaarde, Belgium., Casteels P; Sanofi R&D, Technologiepark 21, 9052 Zwijnaarde, Belgium., De Brabandere V; Sanofi R&D, Technologiepark 21, 9052 Zwijnaarde, Belgium., Jouannot E; Sanofi R&D, 13 Quai Jules Guesde, 94400 Vitry sur Seine, France., Besson FL; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France., Tournier N; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France.
Source: Molecular pharmaceutics [Mol Pharm] 2026 Feb 02; Vol. 23 (2), pp. 975-985. Date of Electronic Publication: 2026 Jan 15.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE
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  Data: Whole-Body Dynamic PET Imaging of Half-Life Extended Variable Domains of Heavy Chain-Only Antibodies: Beyond Blood Pharmacokinetics.
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  Data: <searchLink fieldCode="AU" term="%22Marchal+E%22">Marchal E</searchLink>; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France.<br /><searchLink fieldCode="AU" term="%22Goutal+S%22">Goutal S</searchLink>; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France.<br /><searchLink fieldCode="AU" term="%22Richard+M%22">Richard M</searchLink>; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France.<br /><searchLink fieldCode="AU" term="%22N'Diaye+ER%22">N'Diaye ER</searchLink>; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France.<br /><searchLink fieldCode="AU" term="%22Kuhnast+B%22">Kuhnast B</searchLink>; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France.<br /><searchLink fieldCode="AU" term="%22Truillet+C%22">Truillet C</searchLink>; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France.<br /><searchLink fieldCode="AU" term="%22Chevaleyre+C%22">Chevaleyre C</searchLink>; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France.<br /><searchLink fieldCode="AU" term="%22Hinnen+F%22">Hinnen F</searchLink>; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France.<br /><searchLink fieldCode="AU" term="%22Lemaitre+J%22">Lemaitre J</searchLink>; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-Immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT/UMR-S 1184), 92265 Fontenay-aux-Roses, France.<br /><searchLink fieldCode="AU" term="%22Relouzat+F%22">Relouzat F</searchLink>; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-Immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT/UMR-S 1184), 92265 Fontenay-aux-Roses, France.<br /><searchLink fieldCode="AU" term="%22Van+Bogaert+T%22">Van Bogaert T</searchLink>; Sanofi R&D, Technologiepark 21, 9052 Zwijnaarde, Belgium.<br /><searchLink fieldCode="AU" term="%22Casteels+P%22">Casteels P</searchLink>; Sanofi R&D, Technologiepark 21, 9052 Zwijnaarde, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Brabandere+V%22">De Brabandere V</searchLink>; Sanofi R&D, Technologiepark 21, 9052 Zwijnaarde, Belgium.<br /><searchLink fieldCode="AU" term="%22Jouannot+E%22">Jouannot E</searchLink>; Sanofi R&D, 13 Quai Jules Guesde, 94400 Vitry sur Seine, France.<br /><searchLink fieldCode="AU" term="%22Besson+FL%22">Besson FL</searchLink>; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France.<br /><searchLink fieldCode="AU" term="%22Tournier+N%22">Tournier N</searchLink>; Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Orsay, France.
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  Data: <searchLink fieldCode="JN" term="%22101197791%22">Molecular pharmaceutics</searchLink> [Mol Pharm] 2026 Feb 02; Vol. 23 (2), pp. 975-985. <i>Date of Electronic Publication: </i>2026 Jan 15.
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