Evaluation of fluorometholone as adjunctive medical therapy for trachomatous trichiasis surgery (FLAME): a parallel, double-blind, randomised controlled field trial in the Jimma Zone, Ethiopia.
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| Title: | Evaluation of fluorometholone as adjunctive medical therapy for trachomatous trichiasis surgery (FLAME): a parallel, double-blind, randomised controlled field trial in the Jimma Zone, Ethiopia. |
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| Authors: | Kempen JH; Department of Ophthalmology and Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; Department of Ophthalmology and Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA; Sight for Souls, Bellevue, WA, USA; MCM Eye Unit, MyungSung Christian Medical Center General Hospital and MyungSung Medical College, Addis Ababa, Ethiopia; Department of Ophthalmology, Addis Ababa University School of Medicine, Addis Ababa, Ethiopia. Electronic address: john_kempen@meei.harvard.edu., Abashawl A; Berhan Public Health and Eye Care Consultancy, Addis Ababa, Ethiopia., Mohammed AA; Department of Ophthalmology and Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; Berhan Public Health and Eye Care Consultancy, Addis Ababa, Ethiopia., Dodson S; Fred Hollows Foundation, Addis Ababa, Ethiopia and Melbourne, VIC, Australia., Alemayehu W; Fred Hollows Foundation, Addis Ababa, Ethiopia and Melbourne, VIC, Australia., Jin F; Scheie Eye Institute and Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gemechu A; Fred Hollows Foundation, Addis Ababa, Ethiopia and Melbourne, VIC, Australia., Mengesha AA; Berhan Public Health and Eye Care Consultancy, Addis Ababa, Ethiopia; Department of Ophthalmology, Bahir Dar University College of Medicine and Health Sciences, Bahir Dar, Ethiopia., Kumsa DA; Diseases Prevention and Control Directorate, Oromia Regional Health Bureau, Addis Ababa, Ethiopia., Chen Y; Scheie Eye Institute and Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., McWilliams K; Scheie Eye Institute and Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tulu B; Berhan Public Health and Eye Care Consultancy, Addis Ababa, Ethiopia., Abdela G; Berhan Public Health and Eye Care Consultancy, Addis Ababa, Ethiopia., Megersa A; Fred Hollows Foundation, Addis Ababa, Ethiopia and Melbourne, VIC, Australia., Cheru T; Fred Hollows Foundation, Addis Ababa, Ethiopia and Melbourne, VIC, Australia., Mohammad G; Fred Hollows Foundation, Addis Ababa, Ethiopia and Melbourne, VIC, Australia., Succar T; USC Mann School of Pharmacy, Department of Regulatory and Quality Sciences, University of Southern California, Los Angeles, CA, USA; Department of Ophthalmology, University of Sydney, Sydney, NSW, Australia., Bunya VY; Scheie Eye Institute and Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Frick KD; Carey Business School, Johns Hopkins University, Baltimore, ML, USA., Maguire MG; Scheie Eye Institute and Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Burton MJ; International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, UK; National Institute for Health Research Biomedical Research, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London, UK., Ying GS; Scheie Eye Institute and Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. |
| Corporate Authors: | FLAME Trial Research Group |
| Source: | The Lancet. Global health [Lancet Glob Health] 2026 Mar; Vol. 14 (3), pp. e395-e406. Date of Electronic Publication: 2026 Jan 12. |
| Publication Type: | Journal Article; Randomized Controlled Trial |
| Journal Info: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101613665 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2214-109X (Electronic) Linking ISSN: 2214109X NLM ISO Abbreviation: Lancet Glob Health Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41539314 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Evaluation of fluorometholone as adjunctive medical therapy for trachomatous trichiasis surgery (FLAME): a parallel, double-blind, randomised controlled field trial in the Jimma Zone, Ethiopia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Kempen+JH%22">Kempen JH</searchLink>; Department of Ophthalmology and Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; Department of Ophthalmology and Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA; Sight for Souls, Bellevue, WA, USA; MCM Eye Unit, MyungSung Christian Medical Center General Hospital and MyungSung Medical College, Addis Ababa, Ethiopia; Department of Ophthalmology, Addis Ababa University School of Medicine, Addis Ababa, Ethiopia. Electronic address: john&#95;kempen@meei.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Abashawl+A%22">Abashawl A</searchLink>; Berhan Public Health and Eye Care Consultancy, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Mohammed+AA%22">Mohammed AA</searchLink>; Department of Ophthalmology and Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; Berhan Public Health and Eye Care Consultancy, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Dodson+S%22">Dodson S</searchLink>; Fred Hollows Foundation, Addis Ababa, Ethiopia and Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Alemayehu+W%22">Alemayehu W</searchLink>; Fred Hollows Foundation, Addis Ababa, Ethiopia and Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Jin+F%22">Jin F</searchLink>; Scheie Eye Institute and Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gemechu+A%22">Gemechu A</searchLink>; Fred Hollows Foundation, Addis Ababa, Ethiopia and Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Mengesha+AA%22">Mengesha AA</searchLink>; Berhan Public Health and Eye Care Consultancy, Addis Ababa, Ethiopia; Department of Ophthalmology, Bahir Dar University College of Medicine and Health Sciences, Bahir Dar, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Kumsa+DA%22">Kumsa DA</searchLink>; Diseases Prevention and Control Directorate, Oromia Regional Health Bureau, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Scheie Eye Institute and Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22McWilliams+K%22">McWilliams K</searchLink>; Scheie Eye Institute and Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tulu+B%22">Tulu B</searchLink>; Berhan Public Health and Eye Care Consultancy, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Abdela+G%22">Abdela G</searchLink>; Berhan Public Health and Eye Care Consultancy, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Megersa+A%22">Megersa A</searchLink>; Fred Hollows Foundation, Addis Ababa, Ethiopia and Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Cheru+T%22">Cheru T</searchLink>; Fred Hollows Foundation, Addis Ababa, Ethiopia and Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Mohammad+G%22">Mohammad G</searchLink>; Fred Hollows Foundation, Addis Ababa, Ethiopia and Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Succar+T%22">Succar T</searchLink>; USC Mann School of Pharmacy, Department of Regulatory and Quality Sciences, University of Southern California, Los Angeles, CA, USA; Department of Ophthalmology, University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Bunya+VY%22">Bunya VY</searchLink>; Scheie Eye Institute and Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Frick+KD%22">Frick KD</searchLink>; Carey Business School, Johns Hopkins University, Baltimore, ML, USA.<br /><searchLink fieldCode="AU" term="%22Maguire+MG%22">Maguire MG</searchLink>; Scheie Eye Institute and Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Burton+MJ%22">Burton MJ</searchLink>; International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, UK; National Institute for Health Research Biomedical Research, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London, UK.<br /><searchLink fieldCode="AU" term="%22Ying+GS%22">Ying GS</searchLink>; Scheie Eye Institute and Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22FLAME+Trial+Research+Group%22">FLAME Trial Research Group</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101613665%22">The Lancet. Global health</searchLink> [Lancet Glob Health] 2026 Mar; Vol. 14 (3), pp. e395-e406. <i>Date of Electronic Publication: </i>2026 Jan 12. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101613665 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2214-109X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222214109X%22">2214109X </searchLink><i>NLM ISO Abbreviation: </i>Lancet Glob Health <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41539314 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S2214-109X(25)00493-0 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e395 Titles: – TitleFull: Evaluation of fluorometholone as adjunctive medical therapy for trachomatous trichiasis surgery (FLAME): a parallel, double-blind, randomised controlled field trial in the Jimma Zone, Ethiopia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kempen JH – PersonEntity: Name: NameFull: Abashawl A – PersonEntity: Name: NameFull: Mohammed AA – PersonEntity: Name: NameFull: Dodson S – PersonEntity: Name: NameFull: Alemayehu W – PersonEntity: Name: NameFull: Jin F – PersonEntity: Name: NameFull: Gemechu A – PersonEntity: Name: NameFull: Mengesha AA – PersonEntity: Name: NameFull: Kumsa DA – PersonEntity: Name: NameFull: Chen Y – PersonEntity: Name: NameFull: McWilliams K – PersonEntity: Name: NameFull: Tulu B – PersonEntity: Name: NameFull: Abdela G – PersonEntity: Name: NameFull: Megersa A – PersonEntity: Name: NameFull: Cheru T – PersonEntity: Name: NameFull: Mohammad G – PersonEntity: Name: NameFull: Succar T – PersonEntity: Name: NameFull: Bunya VY – PersonEntity: Name: NameFull: Frick KD – PersonEntity: Name: NameFull: Maguire MG – PersonEntity: Name: NameFull: Burton MJ – PersonEntity: Name: NameFull: Ying GS IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 2026 Mar Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2214-109X Numbering: – Type: volume Value: 14 – Type: issue Value: 3 Titles: – TitleFull: The Lancet. Global health Type: main |
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