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Circulating C-reactive protein influences polygenic risk of inflammatory genes expressed in brain endothelia for Alzheimer's disease.

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Title: Circulating C-reactive protein influences polygenic risk of inflammatory genes expressed in brain endothelia for Alzheimer's disease.
Authors: Huang J; Departments of Medicine Biomedical Genetics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Rehman H; Departments of Medicine Biomedical Genetics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Doan C; Departments of Medicine Biomedical Genetics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Stein TD; Pathology &Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; VA Boston Healthcare System, Boston, MA, USA., Mez J; Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, USA., Ang TFA; Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Tao Q; Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, USA., Au R; Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, USA., Farrer LA; Departments of Medicine Biomedical Genetics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, USA; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA; Departments of Epidemiology, Boston University School of Public Health, Boston, MA, USA., Zhang X; Departments of Medicine Biomedical Genetics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA. Electronic address: zhangxl@bu.edu., Qiu WQ; Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. Electronic address: wqiu67@bu.edu.
Source: Neurobiology of disease [Neurobiol Dis] 2026 Feb; Vol. 219, pp. 107257. Date of Electronic Publication: 2026 Jan 13.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE
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  Data: Circulating C-reactive protein influences polygenic risk of inflammatory genes expressed in brain endothelia for Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Departments of Medicine Biomedical Genetics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rehman+H%22">Rehman H</searchLink>; Departments of Medicine Biomedical Genetics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Doan+C%22">Doan C</searchLink>; Departments of Medicine Biomedical Genetics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Stein+TD%22">Stein TD</searchLink>; Pathology &Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; VA Boston Healthcare System, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mez+J%22">Mez J</searchLink>; Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, USA.<br /><searchLink fieldCode="AU" term="%22Ang+TFA%22">Ang TFA</searchLink>; Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tao+Q%22">Tao Q</searchLink>; Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, USA.<br /><searchLink fieldCode="AU" term="%22Au+R%22">Au R</searchLink>; Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, USA.<br /><searchLink fieldCode="AU" term="%22Farrer+LA%22">Farrer LA</searchLink>; Departments of Medicine Biomedical Genetics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, USA; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA; Departments of Epidemiology, Boston University School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Departments of Medicine Biomedical Genetics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA. Electronic address: zhangxl@bu.edu.<br /><searchLink fieldCode="AU" term="%22Qiu+WQ%22">Qiu WQ</searchLink>; Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. Electronic address: wqiu67@bu.edu.
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  Data: <searchLink fieldCode="JN" term="%229500169%22">Neurobiology of disease</searchLink> [Neurobiol Dis] 2026 Feb; Vol. 219, pp. 107257. <i>Date of Electronic Publication: </i>2026 Jan 13.
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        Value: 10.1016/j.nbd.2026.107257
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        Text: English
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      – TitleFull: Circulating C-reactive protein influences polygenic risk of inflammatory genes expressed in brain endothelia for Alzheimer's disease.
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              Text: 2026 Feb
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