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UQCRC1 deficiency impairs mitophagy via PINK1-dependent mechanisms in Parkinson's disease.

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Title: UQCRC1 deficiency impairs mitophagy via PINK1-dependent mechanisms in Parkinson's disease.
Authors: Li JL; Department of Neurology, National Taiwan University Hospital, Jin-Shan Branch, New Taipei, Taiwan.; PhD Program in Translational Medicine, National Taiwan University and Academia Sinica, Taipei, Taiwan., Huang SY; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan., Huang PY; Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Fu SJ; Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan.; School of Medicine, Fu‑Jen Catholic University, New Taipei City, Taiwan., Tsao YJ; Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan.; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan., Chang W; Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan.; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan., Hong CL; Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan., Hung YC; Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan., Liu PH; Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan., Lai LC; Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan., Lin CH; PhD Program in Translational Medicine, National Taiwan University and Academia Sinica, Taipei, Taiwan. chlin@ntu.edu.tw.; Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. chlin@ntu.edu.tw.; Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. chlin@ntu.edu.tw.; Department of Biomedical engineering, National Taiwan University, Taipei, Taiwan. chlin@ntu.edu.tw., Chiang WC; Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan. wchiang@nycu.edu.tw.; Cancer and Immunology Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. wchiang@nycu.edu.tw., Chan CC; PhD Program in Translational Medicine, National Taiwan University and Academia Sinica, Taipei, Taiwan. chancc1@ntu.edu.tw.; Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan. chancc1@ntu.edu.tw.
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2026 Jan 15; Vol. 12 (1), pp. 48. Date of Electronic Publication: 2026 Jan 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
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  Data: UQCRC1 deficiency impairs mitophagy via PINK1-dependent mechanisms in Parkinson's disease.
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  Data: <searchLink fieldCode="AU" term="%22Li+JL%22">Li JL</searchLink>; Department of Neurology, National Taiwan University Hospital, Jin-Shan Branch, New Taipei, Taiwan.; PhD Program in Translational Medicine, National Taiwan University and Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+SY%22">Huang SY</searchLink>; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+PY%22">Huang PY</searchLink>; Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Fu+SJ%22">Fu SJ</searchLink>; Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan.; School of Medicine, Fu‑Jen Catholic University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsao+YJ%22">Tsao YJ</searchLink>; Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan.; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+W%22">Chang W</searchLink>; Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan.; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hong+CL%22">Hong CL</searchLink>; Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+YC%22">Hung YC</searchLink>; Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+PH%22">Liu PH</searchLink>; Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lai+LC%22">Lai LC</searchLink>; Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CH%22">Lin CH</searchLink>; PhD Program in Translational Medicine, National Taiwan University and Academia Sinica, Taipei, Taiwan. chlin@ntu.edu.tw.; Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. chlin@ntu.edu.tw.; Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. chlin@ntu.edu.tw.; Department of Biomedical engineering, National Taiwan University, Taipei, Taiwan. chlin@ntu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chiang+WC%22">Chiang WC</searchLink>; Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan. wchiang@nycu.edu.tw.; Cancer and Immunology Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. wchiang@nycu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chan+CC%22">Chan CC</searchLink>; PhD Program in Translational Medicine, National Taiwan University and Academia Sinica, Taipei, Taiwan. chancc1@ntu.edu.tw.; Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan. chancc1@ntu.edu.tw.
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