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Bench-to-Bedside Perspectives on Ocular Toxicity of Antibody-Drug Conjugates: Toxicology, Clinical Management and Molecule Optimization.

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Title: Bench-to-Bedside Perspectives on Ocular Toxicity of Antibody-Drug Conjugates: Toxicology, Clinical Management and Molecule Optimization.
Authors: Zhang J; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China., Li W; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China., Li M; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China., Wu G; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China., Ni Y; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China., Du J; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China., Xu G; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China., Duan M; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China., Yang Y; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China., Yu X; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China., Cui C; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China., Liu C; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China., Yu C; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China. yucf@nifdc.org.cn., Wang L; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China. wanglan@nifdc.org.cn.
Source: Pharmaceutical research [Pharm Res] 2026 Feb; Vol. 43 (2), pp. 321-343. Date of Electronic Publication: 2026 Jan 15.
Publication Type: Journal Article; Review
Journal Info: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE
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  Data: Bench-to-Bedside Perspectives on Ocular Toxicity of Antibody-Drug Conjugates: Toxicology, Clinical Management and Molecule Optimization.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China.<br /><searchLink fieldCode="AU" term="%22Wu+G%22">Wu G</searchLink>; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China.<br /><searchLink fieldCode="AU" term="%22Ni+Y%22">Ni Y</searchLink>; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China.<br /><searchLink fieldCode="AU" term="%22Du+J%22">Du J</searchLink>; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China.<br /><searchLink fieldCode="AU" term="%22Xu+G%22">Xu G</searchLink>; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China.<br /><searchLink fieldCode="AU" term="%22Duan+M%22">Duan M</searchLink>; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China.<br /><searchLink fieldCode="AU" term="%22Yu+X%22">Yu X</searchLink>; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China.<br /><searchLink fieldCode="AU" term="%22Cui+C%22">Cui C</searchLink>; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China.<br /><searchLink fieldCode="AU" term="%22Yu+C%22">Yu C</searchLink>; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China. yucf@nifdc.org.cn.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; State Key Laboratory of Drug Regulatory Science, NHC Key Laboratory of Research On Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, National Institutes for Food and Drug Control, Beijing, Zip code: 102629, P.R. China. wanglan@nifdc.org.cn.
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  Data: <searchLink fieldCode="JN" term="%228406521%22">Pharmaceutical research</searchLink> [Pharm Res] 2026 Feb; Vol. 43 (2), pp. 321-343. <i>Date of Electronic Publication: </i>2026 Jan 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Kluwer+Academic%2FPlenum+Publishers%22">Kluwer Academic/Plenum Publishers </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8406521 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-904X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207248741%22">07248741 </searchLink><i>NLM ISO Abbreviation: </i>Pharm Res <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s11095-025-03953-w
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        Text: English
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              Text: 2026 Feb
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              Y: 2026
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