Quantitative Systems Toxicology Modeling with DILIsym to Support Phase 3 Dose Selection for Fezolinetant.
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| Title: | Quantitative Systems Toxicology Modeling with DILIsym to Support Phase 3 Dose Selection for Fezolinetant. |
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| Authors: | Nielsen JC; Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA., Woodhead JL; Simulations Plus, Inc., Research Triangle Park, North Carolina, USA., Howell BA; Simulations Plus, Inc., Research Triangle Park, North Carolina, USA., Shoda LKM; Simulations Plus, Inc., Research Triangle Park, North Carolina, USA., Parasrampuria DA; Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA., Huang J; Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA., Iwai M; Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA., Ottery FD, Wang X; Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA., English M; Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA., Miyazaki K; Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA., Watkins PB; University of North Carolina, Chapel Hill, North Carolina, USA. |
| Source: | Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2026 Apr; Vol. 119 (4), pp. 1016-1024. Date of Electronic Publication: 2026 Jan 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41540842 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Quantitative Systems Toxicology Modeling with DILIsym to Support Phase 3 Dose Selection for Fezolinetant. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Nielsen+JC%22">Nielsen JC</searchLink>; Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Woodhead+JL%22">Woodhead JL</searchLink>; Simulations Plus, Inc., Research Triangle Park, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Howell+BA%22">Howell BA</searchLink>; Simulations Plus, Inc., Research Triangle Park, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Shoda+LKM%22">Shoda LKM</searchLink>; Simulations Plus, Inc., Research Triangle Park, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Parasrampuria+DA%22">Parasrampuria DA</searchLink>; Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Iwai+M%22">Iwai M</searchLink>; Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Ottery+FD%22">Ottery FD</searchLink><br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22English+M%22">English M</searchLink>; Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Miyazaki+K%22">Miyazaki K</searchLink>; Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Watkins+PB%22">Watkins PB</searchLink>; University of North Carolina, Chapel Hill, North Carolina, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220372741%22">Clinical pharmacology and therapeutics</searchLink> [Clin Pharmacol Ther] 2026 Apr; Vol. 119 (4), pp. 1016-1024. <i>Date of Electronic Publication: </i>2026 Jan 16. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372741 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-6535 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200099236%22">00099236 </searchLink><i>NLM ISO Abbreviation: </i>Clin Pharmacol Ther <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41540842 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/cpt.70194 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1016 Titles: – TitleFull: Quantitative Systems Toxicology Modeling with DILIsym to Support Phase 3 Dose Selection for Fezolinetant. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nielsen JC – PersonEntity: Name: NameFull: Woodhead JL – PersonEntity: Name: NameFull: Howell BA – PersonEntity: Name: NameFull: Shoda LKM – PersonEntity: Name: NameFull: Parasrampuria DA – PersonEntity: Name: NameFull: Huang J – PersonEntity: Name: NameFull: Iwai M – PersonEntity: Name: NameFull: Ottery FD – PersonEntity: Name: NameFull: Wang X – PersonEntity: Name: NameFull: English M – PersonEntity: Name: NameFull: Miyazaki K – PersonEntity: Name: NameFull: Watkins PB IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: 2026 Apr Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1532-6535 Numbering: – Type: volume Value: 119 – Type: issue Value: 4 Titles: – TitleFull: Clinical pharmacology and therapeutics Type: main |
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