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Liquid liquid phase separation of the intrinsically disordered protein JPT2 compartmentalizes components of NAADP-evoked Ca2+ signaling.

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Title: Liquid liquid phase separation of the intrinsically disordered protein JPT2 compartmentalizes components of NAADP-evoked Ca2+ signaling.
Authors: Kumar S; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA., Gunaratne GS; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA., Cornish J; The Francis Crick Institute, London, NW1 1AT, UK.; Bind Research, Apex, 1 Tribeca Walk, London, NW1 0QE., Silvey KM; Structural and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK., Mu Q; Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK., Guan Z; Department of Medicinal & Biological Chemistry, University of Toledo College of Pharmacy and Pharmaceutical Sciences, 3000 Arlington Avenue, Toledo, OH 43614, USA., Heller GT; Bind Research, Apex, 1 Tribeca Walk, London, NW1 0QE.; Structural and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK., Slama JT; Department of Medicinal & Biological Chemistry, University of Toledo College of Pharmacy and Pharmaceutical Sciences, 3000 Arlington Avenue, Toledo, OH 43614, USA., Patel S; Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK., Marchant JS; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 11. Date of Electronic Publication: 2026 Jan 11.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Liquid liquid phase separation of the intrinsically disordered protein JPT2 compartmentalizes components of NAADP-evoked Ca<superscript>2+</superscript> signaling.
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  Data: <searchLink fieldCode="AU" term="%22Kumar+S%22">Kumar S</searchLink>; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.<br /><searchLink fieldCode="AU" term="%22Gunaratne+GS%22">Gunaratne GS</searchLink>; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.<br /><searchLink fieldCode="AU" term="%22Cornish+J%22">Cornish J</searchLink>; The Francis Crick Institute, London, NW1 1AT, UK.; Bind Research, Apex, 1 Tribeca Walk, London, NW1 0QE.<br /><searchLink fieldCode="AU" term="%22Silvey+KM%22">Silvey KM</searchLink>; Structural and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Mu+Q%22">Mu Q</searchLink>; Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Guan+Z%22">Guan Z</searchLink>; Department of Medicinal & Biological Chemistry, University of Toledo College of Pharmacy and Pharmaceutical Sciences, 3000 Arlington Avenue, Toledo, OH 43614, USA.<br /><searchLink fieldCode="AU" term="%22Heller+GT%22">Heller GT</searchLink>; Bind Research, Apex, 1 Tribeca Walk, London, NW1 0QE.; Structural and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Slama+JT%22">Slama JT</searchLink>; Department of Medicinal & Biological Chemistry, University of Toledo College of Pharmacy and Pharmaceutical Sciences, 3000 Arlington Avenue, Toledo, OH 43614, USA.<br /><searchLink fieldCode="AU" term="%22Patel+S%22">Patel S</searchLink>; Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Marchant+JS%22">Marchant JS</searchLink>; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.64898/2026.01.10.698830
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              Text: 2026 Jan 11
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