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High-throughput mapping of 6,888 RAD51D variants identifies distinct biochemical functions needed for homologous recombination and olaparib response.

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Title: High-throughput mapping of 6,888 RAD51D variants identifies distinct biochemical functions needed for homologous recombination and olaparib response.
Authors: Darrah KE; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Hemker SL; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Rawal Y; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Goff NJ; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Parker P; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Ganesan G; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Stratton CM; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Oppenheimer K; Department of Pharmacology and Chemical Biology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Roberts E; Department of Pharmacology and Chemical Biology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Glick E; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Banks N; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Kumar A; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Casadei S; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.; Brotman Baty Institute, Seattle, WA 98195, USA., Snyder MW; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.; Brotman Baty Institute, Seattle, WA 98195, USA., Nathanson K; Department of Medicine, Basser Center for BRCA, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Domchek SM; Department of Medicine, Basser Center for BRCA, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Starita LM; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.; Brotman Baty Institute, Seattle, WA 98195, USA., Olsen SK; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Sung P; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Kitzman JO; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Gilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Bernstein KA; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 11. Date of Electronic Publication: 2026 Jan 11.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: High-throughput mapping of 6,888 RAD51D variants identifies distinct biochemical functions needed for homologous recombination and olaparib response.
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  Data: <searchLink fieldCode="AU" term="%22Darrah+KE%22">Darrah KE</searchLink>; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hemker+SL%22">Hemker SL</searchLink>; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Rawal+Y%22">Rawal Y</searchLink>; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Goff+NJ%22">Goff NJ</searchLink>; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Parker+P%22">Parker P</searchLink>; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ganesan+G%22">Ganesan G</searchLink>; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Stratton+CM%22">Stratton CM</searchLink>; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Oppenheimer+K%22">Oppenheimer K</searchLink>; Department of Pharmacology and Chemical Biology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+E%22">Roberts E</searchLink>; Department of Pharmacology and Chemical Biology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Glick+E%22">Glick E</searchLink>; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Banks+N%22">Banks N</searchLink>; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+A%22">Kumar A</searchLink>; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Casadei+S%22">Casadei S</searchLink>; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.; Brotman Baty Institute, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Snyder+MW%22">Snyder MW</searchLink>; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.; Brotman Baty Institute, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Nathanson+K%22">Nathanson K</searchLink>; Department of Medicine, Basser Center for BRCA, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Domchek+SM%22">Domchek SM</searchLink>; Department of Medicine, Basser Center for BRCA, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Starita+LM%22">Starita LM</searchLink>; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.; Brotman Baty Institute, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Olsen+SK%22">Olsen SK</searchLink>; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Sung+P%22">Sung P</searchLink>; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kitzman+JO%22">Kitzman JO</searchLink>; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Gilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Bernstein+KA%22">Bernstein KA</searchLink>; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
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