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RIG-I RNA agonist activates immunostimulatory macrophages to enhance checkpoint immunotherapy for glioblastoma.

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Title: RIG-I RNA agonist activates immunostimulatory macrophages to enhance checkpoint immunotherapy for glioblastoma.
Authors: Xu H; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA., Lee S; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA., Leser F; Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA., Fedorova O; Department of Molecular, Cellular and Developmental Biology, Yale University School of Medicine, New Haven, CT, USA., Lu P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Song E; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT, USA., Touat M; Sorbonne Université, AP-HP, Institut du Cerveau - Paris Brain Institute (ICM), Inserm U1127, CNRS UMR 7225, Service de Neuro-oncologie, Hôpital Pitié-Salpêtrière, Paris, France., Eichmann A; Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.; Paris Cardiovascular Research Center, Inserm U970, Université Paris, Paris, France., Iwasaki A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Center for Infection and Immunity, Yale University School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Pyle AM; Department of Molecular, Cellular and Developmental Biology, Yale University School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Department of Chemistry, Yale University, New Haven, CT 06511, USA., Thomas JL; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.; Sorbonne Université, AP-HP, Institut du Cerveau - Paris Brain Institute (ICM), Inserm U1127, CNRS UMR 7225, Service de Neuro-oncologie, Hôpital Pitié-Salpêtrière, Paris, France.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 08. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: RIG-I RNA agonist activates immunostimulatory macrophages to enhance checkpoint immunotherapy for glioblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Xu+H%22">Xu H</searchLink>; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Lee+S%22">Lee S</searchLink>; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Leser+F%22">Leser F</searchLink>; Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Fedorova+O%22">Fedorova O</searchLink>; Department of Molecular, Cellular and Developmental Biology, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Lu+P%22">Lu P</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Song+E%22">Song E</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Touat+M%22">Touat M</searchLink>; Sorbonne Université, AP-HP, Institut du Cerveau - Paris Brain Institute (ICM), Inserm U1127, CNRS UMR 7225, Service de Neuro-oncologie, Hôpital Pitié-Salpêtrière, Paris, France.<br /><searchLink fieldCode="AU" term="%22Eichmann+A%22">Eichmann A</searchLink>; Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.; Paris Cardiovascular Research Center, Inserm U970, Université Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Iwasaki+A%22">Iwasaki A</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Center for Infection and Immunity, Yale University School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Pyle+AM%22">Pyle AM</searchLink>; Department of Molecular, Cellular and Developmental Biology, Yale University School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Department of Chemistry, Yale University, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Thomas+JL%22">Thomas JL</searchLink>; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.; Sorbonne Université, AP-HP, Institut du Cerveau - Paris Brain Institute (ICM), Inserm U1127, CNRS UMR 7225, Service de Neuro-oncologie, Hôpital Pitié-Salpêtrière, Paris, France.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 Jan 08. <i>Date of Electronic Publication: </i>2026 Jan 08.
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              Text: 2026 Jan 08
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