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Small molecule stabilization of diverse amyloidogenic immunoglobulin light chains revealed by hydrogen-deuterium exchange mass spectrometry.

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Title: Small molecule stabilization of diverse amyloidogenic immunoglobulin light chains revealed by hydrogen-deuterium exchange mass spectrometry.
Authors: Peterle D; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA., Yan NL; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Klimtchuk ES; Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Wales TE; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA., Gursky O; Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Kelly JW; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Engen JR; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA., Morgan GJ; Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Section of Hematology and Medical Oncology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 08. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Small molecule stabilization of diverse amyloidogenic immunoglobulin light chains revealed by hydrogen-deuterium exchange mass spectrometry.
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  Data: <searchLink fieldCode="AU" term="%22Peterle+D%22">Peterle D</searchLink>; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yan+NL%22">Yan NL</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Klimtchuk+ES%22">Klimtchuk ES</searchLink>; Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wales+TE%22">Wales TE</searchLink>; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gursky+O%22">Gursky O</searchLink>; Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kelly+JW%22">Kelly JW</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Engen+JR%22">Engen JR</searchLink>; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Morgan+GJ%22">Morgan GJ</searchLink>; Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Section of Hematology and Medical Oncology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 Jan 08. <i>Date of Electronic Publication: </i>2026 Jan 08.
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        Value: 10.64898/2026.01.07.698275
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              Text: 2026 Jan 08
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