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Nonspecific Cellular Interactions Are a Key Determinant in the Disposition of Fc-Fused Proteins.

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Title: Nonspecific Cellular Interactions Are a Key Determinant in the Disposition of Fc-Fused Proteins.
Authors: Bryniarski MA; Pharmacokinetics and Drug Metabolism, Amgen Research, 750 Gateway Blvd, Suite 100, South San Francisco, California 94080, United States., Wang S; Large Molecule Discovery & Research Data Science, Amgen Research, 750 Gateway Blvd, Suite 100 South, San Francisco, California 94080, United States., Chen A; Large Molecule Discovery & Research Data Science, Amgen Research, 750 Gateway Blvd, Suite 100 South, San Francisco, California 94080, United States., Coventry B; Institute for Protein Design, University of Washington, Seattle, Washington 98105, United States.; Department of Biochemistry, University of Washington, Seattle, Washington 98105, United States.; Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98105, United States., Korkmaz EN; Institute for Protein Design, University of Washington, Seattle, Washington 98105, United States.; Department of Biochemistry, University of Washington, Seattle, Washington 98105, United States., Haque Tuhin MT; Pharmacokinetics and Drug Metabolism, Amgen Research, 750 Gateway Blvd, Suite 100, South San Francisco, California 94080, United States., Ko EC; Pharmacokinetics and Drug Metabolism, Amgen Research, 750 Gateway Blvd, Suite 100, South San Francisco, California 94080, United States., Wakefield DL; Cytometry & Imaging Sciences, Amgen Research, 750 Gateway Blvd, Suite 100 South, San Francisco, California 94080, United States., LaGory EL; Pharmacokinetics and Drug Metabolism, Amgen Research, 750 Gateway Blvd, Suite 100, South San Francisco, California 94080, United States., Wu H; Pharmacokinetics and Drug Metabolism, Amgen Research, 750 Gateway Blvd, Suite 100, South San Francisco, California 94080, United States., Hewage AP; Pharmacokinetics and Drug Metabolism, Amgen Research, 750 Gateway Blvd, Suite 100, South San Francisco, California 94080, United States., Dang K; Large Molecule Discovery & Research Data Science, Amgen Research, 750 Gateway Blvd, Suite 100 South, San Francisco, California 94080, United States., Soto M; Pharmacokinetics & Drug Metabolism, Amgen Research, 1 Amgen Center Drive, Thousand Oaks, California 91320, United States., Ponce M; Pharmacokinetics & Drug Metabolism, Amgen Research, 1 Amgen Center Drive, Thousand Oaks, California 91320, United States., Ojeda E; Pharmacokinetics & Drug Metabolism, Amgen Research, 1 Amgen Center Drive, Thousand Oaks, California 91320, United States., Conner KP; Pharmacokinetics and Drug Metabolism, Amgen Research, 750 Gateway Blvd, Suite 100, South San Francisco, California 94080, United States., Stewart LJ; Institute for Protein Design, University of Washington, Seattle, Washington 98105, United States.; Department of Biochemistry, University of Washington, Seattle, Washington 98105, United States., Tinberg CE; Large Molecule Discovery & Research Data Science, Amgen Research, 750 Gateway Blvd, Suite 100 South, San Francisco, California 94080, United States., Lim AC; Large Molecule Discovery & Research Data Science, Amgen Research, 750 Gateway Blvd, Suite 100 South, San Francisco, California 94080, United States., Baker D; Institute for Protein Design, University of Washington, Seattle, Washington 98105, United States.; Department of Biochemistry, University of Washington, Seattle, Washington 98105, United States.; Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98105, United States., Cook KD; Pharmacokinetics and Drug Metabolism, Amgen Research, 750 Gateway Blvd, Suite 100, South San Francisco, California 94080, United States.
Source: Molecular pharmaceutics [Mol Pharm] 2026 Feb 02; Vol. 23 (2), pp. 859-882. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE
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  Data: <searchLink fieldCode="JN" term="%22101197791%22">Molecular pharmaceutics</searchLink> [Mol Pharm] 2026 Feb 02; Vol. 23 (2), pp. 859-882. <i>Date of Electronic Publication: </i>2026 Jan 16.
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