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Biophysical characterisation of mRNA structure and its impact on integrity analysis by liquid chromatography and capillary gel electrophoresis methods.

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Title: Biophysical characterisation of mRNA structure and its impact on integrity analysis by liquid chromatography and capillary gel electrophoresis methods.
Authors: Elgohary M; Analytical Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom., Webb ALJ; School of Chemical, Materials and Biological Engineering, University of Sheffield, Sheffield, S1 3JD, United Kingdom., Ward JC; Translational Genomics, Centre of Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Murthy A; Purification Process Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom., Hutchinson J; Analytical Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom., Button J; RNA Therapy Team, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB2 0AA, United Kingdom., Thom G; RNA Therapy Team, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB2 0AA, United Kingdom., Newton P; RNA Therapy Team, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB2 0AA, United Kingdom., Hammarvid E; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Baran AD; Translational Genomics, Centre of Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Patel J; Analytical Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom., Turney HN; Analytical Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom., Dickman MJ; School of Chemical, Materials and Biological Engineering, University of Sheffield, Sheffield, S1 3JD, United Kingdom., Trabulo S; Analytical Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom., Örnskov E; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. Electronic address: eivor.ornskov@astrazeneca.com.
Source: Journal of chromatography. A [J Chromatogr A] 2026 Feb 22; Vol. 1769, pp. 466625. Date of Electronic Publication: 2025 Dec 17.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3778 (Electronic) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Elgohary+M%22">Elgohary M</searchLink>; Analytical Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Webb+ALJ%22">Webb ALJ</searchLink>; School of Chemical, Materials and Biological Engineering, University of Sheffield, Sheffield, S1 3JD, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ward+JC%22">Ward JC</searchLink>; Translational Genomics, Centre of Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Murthy+A%22">Murthy A</searchLink>; Purification Process Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hutchinson+J%22">Hutchinson J</searchLink>; Analytical Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Button+J%22">Button J</searchLink>; RNA Therapy Team, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Thom+G%22">Thom G</searchLink>; RNA Therapy Team, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Newton+P%22">Newton P</searchLink>; RNA Therapy Team, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hammarvid+E%22">Hammarvid E</searchLink>; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Baran+AD%22">Baran AD</searchLink>; Translational Genomics, Centre of Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Patel+J%22">Patel J</searchLink>; Analytical Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Turney+HN%22">Turney HN</searchLink>; Analytical Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dickman+MJ%22">Dickman MJ</searchLink>; School of Chemical, Materials and Biological Engineering, University of Sheffield, Sheffield, S1 3JD, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Trabulo+S%22">Trabulo S</searchLink>; Analytical Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Örnskov+E%22">Örnskov E</searchLink>; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. Electronic address: eivor.ornskov@astrazeneca.com.
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