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Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations.

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Title: Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations.
Authors: Hafner P; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Keller SJ; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Chen X; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China., Alrawashdeh A; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Jumaa H; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Nollmann FI; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Besson S; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Kemming J; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Gorka O; Institute of Neuropathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Das T; Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Appiah B; Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Lehmann A; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Li M; Institute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Apostolova P; Division of Hematology, University Hospital Basel, Basel, Switzerland., Bengsch B; Department of Internal Medicine II, Medical Center - University of Freiburg, Freiburg, Germany.; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany., Zeiser R; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany.; Department of Medicine I, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Tholen S; Institute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Schilling O; Institute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Groß O; Institute of Neuropathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany., Vlachos A; Faculty of Medicine, Department of Neuroanatomy - University of Freiburg, Freiburg, Germany., Wittel UA; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., von Elverfeldt D; Division of Medical Physics, Department of Diagnostic and Interventional Radiology, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany., Reichardt W; Division of Medical Physics, Department of Diagnostic and Interventional Radiology, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany., Boerries M; Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany., Andrieux G; Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Heynen GJ; Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, Berlin, Germany., Fichtner-Feigl S; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Hannibal L; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.; Department of Pediatrics, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Ruess DA; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany. dietrich.ruess@uniklinik-freiburg.de.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany. dietrich.ruess@uniklinik-freiburg.de.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jan 16; Vol. 11 (1), pp. 33. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
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  Data: Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations.
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  Data: <searchLink fieldCode="AU" term="%22Hafner+P%22">Hafner P</searchLink>; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Keller+SJ%22">Keller SJ</searchLink>; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Alrawashdeh+A%22">Alrawashdeh A</searchLink>; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Jumaa+H%22">Jumaa H</searchLink>; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Nollmann+FI%22">Nollmann FI</searchLink>; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Besson+S%22">Besson S</searchLink>; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kemming+J%22">Kemming J</searchLink>; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; 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Institute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Apostolova+P%22">Apostolova P</searchLink>; Division of Hematology, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bengsch+B%22">Bengsch B</searchLink>; Department of Internal Medicine II, Medical Center - University of Freiburg, Freiburg, Germany.; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Zeiser+R%22">Zeiser R</searchLink>; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany.; Department of Medicine I, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Tholen+S%22">Tholen S</searchLink>; Institute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schilling+O%22">Schilling O</searchLink>; Institute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Groß+O%22">Groß O</searchLink>; Institute of Neuropathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Vlachos+A%22">Vlachos A</searchLink>; Faculty of Medicine, Department of Neuroanatomy - University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wittel+UA%22">Wittel UA</searchLink>; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22von+Elverfeldt+D%22">von Elverfeldt D</searchLink>; Division of Medical Physics, Department of Diagnostic and Interventional Radiology, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Reichardt+W%22">Reichardt W</searchLink>; Division of Medical Physics, Department of Diagnostic and Interventional Radiology, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Boerries+M%22">Boerries M</searchLink>; Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Andrieux+G%22">Andrieux G</searchLink>; Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Heynen+GJ%22">Heynen GJ</searchLink>; Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Fichtner-Feigl+S%22">Fichtner-Feigl S</searchLink>; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hannibal+L%22">Hannibal L</searchLink>; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.; Department of Pediatrics, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ruess+DA%22">Ruess DA</searchLink>; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany. dietrich.ruess@uniklinik-freiburg.de.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany. dietrich.ruess@uniklinik-freiburg.de.
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