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Metabolic dysfunction-associated steatotic liver disease accelerates pancreatic cancer progression and metastasis via the macrophage migration inhibitory factor-CD44 axis.

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Title: Metabolic dysfunction-associated steatotic liver disease accelerates pancreatic cancer progression and metastasis via the macrophage migration inhibitory factor-CD44 axis.
Authors: Yu Q; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Song H; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Shi XY; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Zhu L; Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China., Liang Y; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Gong RN; Gastrointestinal Cancer Institute (Pancreatic Disease Institute), the Affiliated Hospital of Qingdao University, Qingdao, China., Dong XW; Pancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, the Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China., Liu SL; Department of Gastrointestinal Surgery, the Affiliated Hospital of Qingdao University, Qingdao, China., Wang HZ; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Wang YL; Department of Endocrinology and Metabolism, the Affiliated Hospital of Qingdao University, Qingdao, China., Cui JF; Department of Radiology, the Affiliated Hospital of Qingdao University, Qingdao, China., Yang XN; Department of Radiology, the Affiliated Hospital of Qingdao University, Qingdao, China., Chen Y; Department of Endocrinology and Metabolism, the Affiliated Hospital of Qingdao University, Qingdao, China., Gao C; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Yang Z; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Zhu QT; Pancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, the Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China., Li C; School of Biomedical Sciences, the Chinese University of Hong Kong, Hong Kong, China., Zhang H; Department of Food Science and Nutrition and Research Center for Chinese Medicine Innovation, the Hong Kong Polytechnic University, Hong Kong, China., Ying JE; Department of Pancreatic and Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou, China., Zheng MF; Department of Pancreatic and Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou, China., Tian YT; Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Hu HT; Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Shao XX; Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Li Y; Department of Medicinal Chemistry, Immunophage Biotech Co. Ltd, Nanjing, China., Mo MG; Department of Medicinal Chemistry, Cobio Biotechnology Co. Ltd, Shanghai, China., Lu Y; Department of Gastrointestinal Surgery, the Affiliated Hospital of Qingdao University, Qingdao, China., Ma Z; Department of Gastrointestinal Surgery, the Affiliated Hospital of Qingdao University, Qingdao, China., Fu SL; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Niu QH; Department of Liver Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China., Liao YY; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Zhao CY; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Liu X; Department of Gastroenterology, Zigong Fourth People's Hospital, Zigong, China., Saluja AK; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.; Pancreas Center, Center for Interventional Endoscopy, AdventHealth Orland, Orlando, FL, USA., Wang JG; Department of Pathology, the Affiliated Hospital of Qingdao University, Qingdao, China., Li XY; Department of Gastroenterology, the Affiliated Hospital of Qingdao University, Qingdao, China., Guo SY; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Wang WH; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Wang S; Department of Gastrointestinal Surgery, the Affiliated Hospital of Qingdao University, Qingdao, China., Liu B; Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China., Lu GT; Pancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, the Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China. gtlu@yzu.edu.cn., Ren H; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China. herenrh@163.com.; Gastrointestinal Cancer Institute (Pancreatic Disease Institute), the Affiliated Hospital of Qingdao University, Qingdao, China. herenrh@163.com.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jan 16; Vol. 11 (1), pp. 32. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Metabolic dysfunction-associated steatotic liver disease accelerates pancreatic cancer progression and metastasis via the macrophage migration inhibitory factor-CD44 axis.
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  Data: <searchLink fieldCode="AU" term="%22Yu+Q%22">Yu Q</searchLink>; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Song+H%22">Song H</searchLink>; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Shi+XY%22">Shi XY</searchLink>; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Zhu+L%22">Zhu L</searchLink>; Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Liang+Y%22">Liang Y</searchLink>; 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