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Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals.

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Title: Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals.
Authors: Dholakia V; Department of Pathobiology and Population Sciences, Royal Veterinary College, London, UK., Quantrill JL; Department of Infectious Disease, Imperial College London, London, UK.; The Pirbright Institute, Woking, UK., Richardson SAS; The Pirbright Institute, Woking, UK., Pankaew N; The Roslin Institute, University of Edinburgh, Edinburgh, UK., Brown MD; Department of Infectious Disease, Imperial College London, London, UK., Yang J; The Pirbright Institute, Woking, UK., Capelastegui F; Department of Pathobiology and Population Sciences, Royal Veterinary College, London, UK., Masonou T; Great Ormond Street UCL Institute of Child Health, London, UK., Case KM; Great Ormond Street UCL Institute of Child Health, London, UK., Ajeian J; Great Ormond Street UCL Institute of Child Health, London, UK., Woodall MNJ; Great Ormond Street UCL Institute of Child Health, London, UK., Magill C; MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK., Freimanis G; The Pirbright Institute, Woking, UK., McCarron A; The Pirbright Institute, Woking, UK., Staller E; Sir William Dunn School of Pathology, The University of Oxford, Oxford, UK., Sheppard CM; Department of Infectious Disease, Imperial College London, London, UK., Brown IH; The Pirbright Institute, Woking, UK., Murcia PR; MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK., Smith CM; Great Ormond Street UCL Institute of Child Health, London, UK., Iqbal M; The Pirbright Institute, Woking, UK., Digard P; The Roslin Institute, University of Edinburgh, Edinburgh, UK., Barclay WS; Department of Infectious Disease, Imperial College London, London, UK., Pinto RM; The Roslin Institute, University of Edinburgh, Edinburgh, UK. rpinto2@exseed.ed.ac.uk., Peacock TP; Department of Infectious Disease, Imperial College London, London, UK. tom.peacock@pirbright.ac.uk.; The Pirbright Institute, Woking, UK. tom.peacock@pirbright.ac.uk., Goldhill DH; Department of Pathobiology and Population Sciences, Royal Veterinary College, London, UK. dgoldhill@rvc.ac.uk.
Source: Nature communications [Nat Commun] 2026 Jan 16; Vol. 17 (1), pp. 1603. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals.
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  Data: <searchLink fieldCode="AU" term="%22Dholakia+V%22">Dholakia V</searchLink>; Department of Pathobiology and Population Sciences, Royal Veterinary College, London, UK.<br /><searchLink fieldCode="AU" term="%22Quantrill+JL%22">Quantrill JL</searchLink>; Department of Infectious Disease, Imperial College London, London, UK.; The Pirbright Institute, Woking, UK.<br /><searchLink fieldCode="AU" term="%22Richardson+SAS%22">Richardson SAS</searchLink>; The Pirbright Institute, Woking, UK.<br /><searchLink fieldCode="AU" term="%22Pankaew+N%22">Pankaew N</searchLink>; The Roslin Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Brown+MD%22">Brown MD</searchLink>; Department of Infectious Disease, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; The Pirbright Institute, Woking, UK.<br /><searchLink fieldCode="AU" term="%22Capelastegui+F%22">Capelastegui F</searchLink>; Department of Pathobiology and Population Sciences, Royal Veterinary College, London, UK.<br /><searchLink fieldCode="AU" term="%22Masonou+T%22">Masonou T</searchLink>; Great Ormond Street UCL Institute of Child Health, London, UK.<br /><searchLink fieldCode="AU" term="%22Case+KM%22">Case KM</searchLink>; Great Ormond Street UCL Institute of Child Health, London, UK.<br /><searchLink fieldCode="AU" term="%22Ajeian+J%22">Ajeian J</searchLink>; Great Ormond Street UCL Institute of Child Health, London, UK.<br /><searchLink fieldCode="AU" term="%22Woodall+MNJ%22">Woodall MNJ</searchLink>; Great Ormond Street UCL Institute of Child Health, London, UK.<br /><searchLink fieldCode="AU" term="%22Magill+C%22">Magill C</searchLink>; MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Freimanis+G%22">Freimanis G</searchLink>; The Pirbright Institute, Woking, UK.<br /><searchLink fieldCode="AU" term="%22McCarron+A%22">McCarron A</searchLink>; The Pirbright Institute, Woking, UK.<br /><searchLink fieldCode="AU" term="%22Staller+E%22">Staller E</searchLink>; Sir William Dunn School of Pathology, The University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Sheppard+CM%22">Sheppard CM</searchLink>; Department of Infectious Disease, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Brown+IH%22">Brown IH</searchLink>; The Pirbright Institute, Woking, UK.<br /><searchLink fieldCode="AU" term="%22Murcia+PR%22">Murcia PR</searchLink>; MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Smith+CM%22">Smith CM</searchLink>; Great Ormond Street UCL Institute of Child Health, London, UK.<br /><searchLink fieldCode="AU" term="%22Iqbal+M%22">Iqbal M</searchLink>; The Pirbright Institute, Woking, UK.<br /><searchLink fieldCode="AU" term="%22Digard+P%22">Digard P</searchLink>; The Roslin Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Barclay+WS%22">Barclay WS</searchLink>; Department of Infectious Disease, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Pinto+RM%22">Pinto RM</searchLink>; The Roslin Institute, University of Edinburgh, Edinburgh, UK. rpinto2@exseed.ed.ac.uk.<br /><searchLink fieldCode="AU" term="%22Peacock+TP%22">Peacock TP</searchLink>; Department of Infectious Disease, Imperial College London, London, UK. tom.peacock@pirbright.ac.uk.; The Pirbright Institute, Woking, UK. tom.peacock@pirbright.ac.uk.<br /><searchLink fieldCode="AU" term="%22Goldhill+DH%22">Goldhill DH</searchLink>; Department of Pathobiology and Population Sciences, Royal Veterinary College, London, UK. dgoldhill@rvc.ac.uk.
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