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Chronic melamine cyanurate exposure impairs spatial learning and memory by altering autophagy-mediated synaptic plasticity and oxidative stress in the hippocampus of adolescent rats.

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Title: Chronic melamine cyanurate exposure impairs spatial learning and memory by altering autophagy-mediated synaptic plasticity and oxidative stress in the hippocampus of adolescent rats.
Authors: Sun W; Department of NeonatologyThe First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China.; Department of ProctologyThe First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China., Lai X; Department of ProctologyThe First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China., Wan Y; Department of Rehabilitation Medicine, Shenzhen Bao'an Hospital Affiliated of Southern Medical University, Shenzhen, 518100, Guangdong, China., Mei Y; Graduate School of Guangzhou University of Chinese Medicine, Guangzhou, 510006, China., Li X; Department of Neurology, Jinan Geriatric/Rehabilitation Hospital, Jinan, 250013, China., Yang Y; Department of ProctologyThe First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China., An L; Department of NeonatologyThe First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China. al_totti@sina.com.; Department of ProctologyThe First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China. al_totti@sina.com.; Graduate School of Guangzhou University of Chinese Medicine, Guangzhou, 510006, China. al_totti@sina.com.
Source: Archives of toxicology [Arch Toxicol] 2026 Apr; Vol. 100 (4), pp. 1551-1564. Date of Electronic Publication: 2026 Jan 17.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0738
DOI:10.1007/s00204-025-04289-5