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Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers: a phase 1b/2 trial.

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Title: Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers: a phase 1b/2 trial.
Authors: D'Alise AM; Nouscom SRL, Rome, Italy., Willis J; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Duzagac F; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hall MJ; Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA., Cruz-Correa M; University of Puerto Rico Medical Sciences Campus, San Juan, PR, USA., Idos GE; City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Thirumurthi S; Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ballester V; University of Puerto Rico Medical Sciences Campus, San Juan, PR, USA., Leoni G; Nouscom SRL, Rome, Italy., Garzia I; Nouscom SRL, Rome, Italy., Antonucci L; Nouscom SRL, Rome, Italy., De Marco L; Nouscom SRL, Rome, Italy., Micarelli E; Nouscom SRL, Rome, Italy., Deng N; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Seclì L; Nouscom SRL, Rome, Italy., Gogov S; Nouscom AG, Basel, Switzerland., Dong W; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Jack Lee J; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bowen CM; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Vornik LA; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Garcia-Gonzalez A; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Reyes-Uribe L; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Richmond E; Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA., Umar A; Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA., Brown PH; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sinha KM; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rodriguez LM; Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA.; Department of Surgery, Walter Reed National Military Medical Center, Bethesda, MD, USA., Scarselli E; Nouscom SRL, Rome, Italy. e.scarselli@nouscom.com., Vilar E; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. EVilar@mdanderson.org.
Source: Nature medicine [Nat Med] 2026 Mar; Vol. 32 (3), pp. 1002-1011. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article; Clinical Trial, Phase I; Clinical Trial, Phase II
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22D'Alise+AM%22">D'Alise AM</searchLink>; Nouscom SRL, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Willis+J%22">Willis J</searchLink>; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Duzagac+F%22">Duzagac F</searchLink>; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hall+MJ%22">Hall MJ</searchLink>; Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cruz-Correa+M%22">Cruz-Correa M</searchLink>; University of Puerto Rico Medical Sciences Campus, San Juan, PR, USA.<br /><searchLink fieldCode="AU" term="%22Idos+GE%22">Idos GE</searchLink>; City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Thirumurthi+S%22">Thirumurthi S</searchLink>; Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ballester+V%22">Ballester V</searchLink>; University of Puerto Rico Medical Sciences Campus, San Juan, PR, USA.<br /><searchLink fieldCode="AU" term="%22Leoni+G%22">Leoni G</searchLink>; Nouscom SRL, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Garzia+I%22">Garzia I</searchLink>; Nouscom SRL, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Antonucci+L%22">Antonucci L</searchLink>; Nouscom SRL, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22De+Marco+L%22">De Marco L</searchLink>; Nouscom SRL, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Micarelli+E%22">Micarelli E</searchLink>; Nouscom SRL, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Deng+N%22">Deng N</searchLink>; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Seclì+L%22">Seclì L</searchLink>; Nouscom SRL, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Gogov+S%22">Gogov S</searchLink>; Nouscom AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dong+W%22">Dong W</searchLink>; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Jack+Lee+J%22">Jack Lee J</searchLink>; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Bowen+CM%22">Bowen CM</searchLink>; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Vornik+LA%22">Vornik LA</searchLink>; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Garcia-Gonzalez+A%22">Garcia-Gonzalez A</searchLink>; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Reyes-Uribe+L%22">Reyes-Uribe L</searchLink>; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Richmond+E%22">Richmond E</searchLink>; Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Umar+A%22">Umar A</searchLink>; Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Brown+PH%22">Brown PH</searchLink>; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Sinha+KM%22">Sinha KM</searchLink>; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+LM%22">Rodriguez LM</searchLink>; Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA.; Department of Surgery, Walter Reed National Military Medical Center, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Scarselli+E%22">Scarselli E</searchLink>; Nouscom SRL, Rome, Italy. e.scarselli@nouscom.com.<br /><searchLink fieldCode="AU" term="%22Vilar+E%22">Vilar E</searchLink>; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. EVilar@mdanderson.org.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2026 Mar; Vol. 32 (3), pp. 1002-1011. <i>Date of Electronic Publication: </i>2026 Jan 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Company%22">Nature Publishing Company </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502015 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-170X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210788956%22">10788956 </searchLink><i>NLM ISO Abbreviation: </i>Nat Med <i>Subsets: </i>MEDLINE
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