Strong constitutive NF-κB signaling in B cells drives SLL/CLL-like lymphomagenesis and overcomes microenvironmental dependencies.
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| Title: | Strong constitutive NF-κB signaling in B cells drives SLL/CLL-like lymphomagenesis and overcomes microenvironmental dependencies. |
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| Authors: | Soberón V; Institute for Experimental Hematology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Max-Planck Institute of Biochemistry, Planegg, Germany., Osswald L; Institute for Experimental Hematology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany.; Department of Medicine III, School of Medicine and Health, Technical University of Munich, Munich, Germany., Moore A; Department of Haematology, University of Cambridge, Cambridge, UK.; Cancer Institute, University College London, London, UK., Sosnowska D; Cancer Institute, University College London, London, UK., Swinerd G; Institute for Experimental Hematology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany., Chen J; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, PR China., Baygün S; Institute for Experimental Hematology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Diehl C; Institute for Experimental Hematology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany., Seyhan G; Institute for Experimental Hematology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany., Kraus L; Institute for Experimental Hematology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany., Gölling V; Institute for Experimental Hematology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany., Trapp R; Institute for Experimental Hematology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany., O'Neill TJ; Research Unit Signaling and Translation, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Bortoluzzi S; Institute for Experimental Hematology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany., Kovacs D; Institute for Experimental Hematology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany., Ammon T; Institute for Experimental Hematology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany., Singroul P; Institute for Experimental Hematology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany., Hubarzhevska Y; Institute for Experimental Hematology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany., Öllinger R; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, Technical University of Munich, Munich, Germany., Mueller S; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, Technical University of Munich, Munich, Germany., Baranov O; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, Technical University of Munich, Munich, Germany., Giansanti P; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany.; Bavarian Center for Biomolecular Mass Spectrometry at Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, Munich, Germany., Gillhuber F; Division of Evolutionary Biology, Faculty of Biology, Ludwig-Maximilians-Universität (LMU) München, Planegg-Martinsried, Germany., Grath S; Division of Evolutionary Biology, Faculty of Biology, Ludwig-Maximilians-Universität (LMU) München, Planegg-Martinsried, Germany., Weigert O; German Cancer Consortium (DKTK), Heidelberg, Germany.; Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Faculty of Medicine, Department of Medicine III, Ludwig-Maximilians-University, Munich, Germany., Rosenwald A; Institute of Pathology, University of Würzburg, Würzburg, Germany., Sasaki Y; Program in Cellular and Molecular Medicine, Children's Hospital, and Immune Disease Institute, Harvard Medical School, Boston, MA, USA.; Division of Immunology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan., Rajewsky K; Program in Cellular and Molecular Medicine, Children's Hospital, and Immune Disease Institute, Harvard Medical School, Boston, MA, USA.; Immune Regulation and Cancer, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Steiger K; German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany., Bassermann F; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Medicine III, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany., Rad R; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, Technical University of Munich, Munich, Germany., Krappmann D; Research Unit Signaling and Translation, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Ringshausen I; Department of Haematology, University of Cambridge, Cambridge, UK.; Cancer Institute, University College London, London, UK., Schmidt-Supprian M; Institute for Experimental Hematology, School of Medicine and Health, Technical University of Munich, Munich, Germany. marc.supprian@tum.de.; Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany. marc.supprian@tum.de.; German Cancer Consortium (DKTK), Heidelberg, Germany. marc.supprian@tum.de.; Max-Planck Institute of Biochemistry, Planegg, Germany. marc.supprian@tum.de.; Program in Cellular and Molecular Medicine, Children's Hospital, and Immune Disease Institute, Harvard Medical School, Boston, MA, USA. marc.supprian@tum.de. |
| Source: | Leukemia [Leukemia] 2026 Mar; Vol. 40 (3), pp. 522-539. Date of Electronic Publication: 2026 Jan 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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