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PPARβ/δ contributes to the antidiabetic effect and the increase in GDF15 caused by metformin.

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Title: PPARβ/δ contributes to the antidiabetic effect and the increase in GDF15 caused by metformin.
Authors: Jurado-Aguilar J; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, 08028, Barcelona, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain.; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain., Barroso E; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, 08028, Barcelona, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain.; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain., Rada P; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain.; Instituto de Investigaciones Biomédicas Sols-Morreale (CSIC/UAM), Madrid, Spain., Peyman M; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, 08028, Barcelona, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain.; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain., Rostami A; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, 08028, Barcelona, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain.; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain., Balsinde J; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain.; Instituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas, Valladolid, Spain., Valverde ÁM; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain.; Instituto de Investigaciones Biomédicas Sols-Morreale (CSIC/UAM), Madrid, Spain., Wahli W; Center for Integrative Genomics, University of Lausanne, CH-, Lausanne, Switzerland.; ToxAlim (Research Center in Food Toxicology), INRAE UMR1331, F-31300, Toulouse Cedex, France., Palomer X; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, 08028, Barcelona, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain.; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain., Vázquez-Carrera M; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain. mvazquezcarrera@ub.edu.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, 08028, Barcelona, Spain. mvazquezcarrera@ub.edu.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain. mvazquezcarrera@ub.edu.; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain. mvazquezcarrera@ub.edu.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 May; Vol. 47 (5), pp. 1219-1232. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Jurado-Aguilar+J%22">Jurado-Aguilar J</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, 08028, Barcelona, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain.; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Barroso+E%22">Barroso E</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, 08028, Barcelona, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain.; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Rada+P%22">Rada P</searchLink>; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain.; Instituto de Investigaciones Biomédicas Sols-Morreale (CSIC/UAM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Peyman+M%22">Peyman M</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, 08028, Barcelona, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain.; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Rostami+A%22">Rostami A</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, 08028, Barcelona, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain.; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Balsinde+J%22">Balsinde J</searchLink>; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain.; Instituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Valverde+ÁM%22">Valverde ÁM</searchLink>; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain.; Instituto de Investigaciones Biomédicas Sols-Morreale (CSIC/UAM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Wahli+W%22">Wahli W</searchLink>; Center for Integrative Genomics, University of Lausanne, CH-, Lausanne, Switzerland.; ToxAlim (Research Center in Food Toxicology), INRAE UMR1331, F-31300, Toulouse Cedex, France.<br /><searchLink fieldCode="AU" term="%22Palomer+X%22">Palomer X</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, 08028, Barcelona, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain.; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Vázquez-Carrera+M%22">Vázquez-Carrera M</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain. mvazquezcarrera@ub.edu.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, 08028, Barcelona, Spain. mvazquezcarrera@ub.edu.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029, Madrid, Spain. mvazquezcarrera@ub.edu.; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain. mvazquezcarrera@ub.edu.
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