High incidence of intrahepatic cholangiocarcinoma in end-stage renal disease patients in Taiwan: analysis of a nationwide database with molecular insight of aristolochic acid exposure.

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Title: High incidence of intrahepatic cholangiocarcinoma in end-stage renal disease patients in Taiwan: analysis of a nationwide database with molecular insight of aristolochic acid exposure.
Authors: Huang SC; Department of Anatomic Pathology, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan., Chang IY; Molecular Medicine Research Center, Chang Gung University, Taoyuan City, Taiwan.; Department of Neurosurgery, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan.; Genomic Medicine Core Laboratory, Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan., Wu LC; Trans-Omics Laboratory for Precision Medicine, Chi Mei Medical Center, Tainan, Taiwan.; Institute of Biomedical Sciences, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan., Hung MY; Trans-Omics Laboratory for Precision Medicine, Chi Mei Medical Center, Tainan, Taiwan.; Institute of Precision Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan., Chuang HC; Department of Anatomic Pathology, College of Medicine, Chiayi Chang Gung Memorial Hospital, Chang Gung University, Chiayi, Taiwan., Ho CH; Department of Medical Research, Chi Mei Medical Center, Yung Kang Dist, 901 Chunghwa Road, Tainan City, 710, Taiwan.; Department of Information Management, Southern Taiwan University of Science and Technology, Tainan City, Taiwan.; Cancer Center, Taipei Municipal Wanfang Hospital, Taipei Medical University, Taipei, Taiwan., Chen TC; Department of Anatomic Pathology, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan., Chiu CC; Trans-Omics Laboratory for Precision Medicine, Chi Mei Medical Center, Tainan, Taiwan.; Department of Electrical Engineering, National Cheng Kung University, Tainan, Taiwan., Chen CC; Department of Radiology, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan., Chen KH; Department of Anatomic Pathology, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan., Yeh TS; Department of Surgery, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan., Hsu JT; Department of Surgery, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan., Ng KF; Department of Anatomic Pathology, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan., Li CF; Department of Medical Research, Chi Mei Medical Center, Yung Kang Dist, 901 Chunghwa Road, Tainan City, 710, Taiwan. angelo.p@yahoo.com.tw.; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan. angelo.p@yahoo.com.tw.; Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan. angelo.p@yahoo.com.tw.
Source: Virchows Archiv : an international journal of pathology [Virchows Arch] 2026 Mar; Vol. 488 (3), pp. 557-568. Date of Electronic Publication: 2026 Jan 17.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 9423843 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2307 (Electronic) Linking ISSN: 09456317 NLM ISO Abbreviation: Virchows Arch Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: High incidence of intrahepatic cholangiocarcinoma in end-stage renal disease patients in Taiwan: analysis of a nationwide database with molecular insight of aristolochic acid exposure.
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  Data: <searchLink fieldCode="AU" term="%22Huang+SC%22">Huang SC</searchLink>; Department of Anatomic Pathology, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+IY%22">Chang IY</searchLink>; Molecular Medicine Research Center, Chang Gung University, Taoyuan City, Taiwan.; Department of Neurosurgery, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan.; Genomic Medicine Core Laboratory, Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+LC%22">Wu LC</searchLink>; Trans-Omics Laboratory for Precision Medicine, Chi Mei Medical Center, Tainan, Taiwan.; Institute of Biomedical Sciences, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+MY%22">Hung MY</searchLink>; Trans-Omics Laboratory for Precision Medicine, Chi Mei Medical Center, Tainan, Taiwan.; Institute of Precision Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chuang+HC%22">Chuang HC</searchLink>; Department of Anatomic Pathology, College of Medicine, Chiayi Chang Gung Memorial Hospital, Chang Gung University, Chiayi, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ho+CH%22">Ho CH</searchLink>; Department of Medical Research, Chi Mei Medical Center, Yung Kang Dist, 901 Chunghwa Road, Tainan City, 710, Taiwan.; Department of Information Management, Southern Taiwan University of Science and Technology, Tainan City, Taiwan.; Cancer Center, Taipei Municipal Wanfang Hospital, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+TC%22">Chen TC</searchLink>; Department of Anatomic Pathology, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiu+CC%22">Chiu CC</searchLink>; Trans-Omics Laboratory for Precision Medicine, Chi Mei Medical Center, Tainan, Taiwan.; Department of Electrical Engineering, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CC%22">Chen CC</searchLink>; Department of Radiology, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+KH%22">Chen KH</searchLink>; Department of Anatomic Pathology, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+TS%22">Yeh TS</searchLink>; Department of Surgery, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+JT%22">Hsu JT</searchLink>; Department of Surgery, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ng+KF%22">Ng KF</searchLink>; Department of Anatomic Pathology, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+CF%22">Li CF</searchLink>; Department of Medical Research, Chi Mei Medical Center, Yung Kang Dist, 901 Chunghwa Road, Tainan City, 710, Taiwan. angelo.p@yahoo.com.tw.; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan. angelo.p@yahoo.com.tw.; Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan. angelo.p@yahoo.com.tw.
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  Data: <searchLink fieldCode="JN" term="%229423843%22">Virchows Archiv : an international journal of pathology</searchLink> [Virchows Arch] 2026 Mar; Vol. 488 (3), pp. 557-568. <i>Date of Electronic Publication: </i>2026 Jan 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International%22">Springer International </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>9423843 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-2307 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209456317%22">09456317 </searchLink><i>NLM ISO Abbreviation: </i>Virchows Arch <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00428-025-04388-9
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        Text: English
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      – TitleFull: High incidence of intrahepatic cholangiocarcinoma in end-stage renal disease patients in Taiwan: analysis of a nationwide database with molecular insight of aristolochic acid exposure.
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              Text: 2026 Mar
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