Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice.
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| Title: | Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice. |
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| Authors: | Tabor GT; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA; Medical Scientist Training Program, Washington University, St. Louis, MO, USA., Litvinchuk A; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Chen Y; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Allison A; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Sun EW; Tenvie Therapeutics, Inc., South San Francisco, CA, USA., van Lengerich B; Denali Therapeutics, Inc., South San Francisco, CA, USA., Davis SS; Denali Therapeutics, Inc., South San Francisco, CA, USA., West E; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Schlachetzki JCM; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA., Zeng C; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA., Hu H; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Lin PB; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Sharma P; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Chen X; Laboratory of System Neuroimmunology, Institute for Immunology, IDG/McGovern Institute for Brain Research, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China., Parhizkar S; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Song S; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Bao X; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Senthil L; University of Chicago, Chicago, IL, USA., Iyer AK; Department of Psychiatry, Washington University, St. Louis, MO, USA., You SF; Department of Psychiatry, Washington University, St. Louis, MO, USA., Serrano JR; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Manis M; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Franke E; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Cashikar AG; Department of Psychiatry, Washington University, St. Louis, MO, USA., Yuede CM; Department of Psychiatry, Washington University, St. Louis, MO, USA., Suh JH; Denali Therapeutics, Inc., South San Francisco, CA, USA., Karch CM; Department of Psychiatry, Washington University, St. Louis, MO, USA., Folick A; Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Francisco, San Francisco CA, USA., Koliwad SK; Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Francisco, San Francisco CA, USA., Farese RV Jr; Cell Biology Program, Sloan Kettering Institute, New York, NY, USA., Walther T; Cell Biology Program, Sloan Kettering Institute, New York, NY, USA; Howard Hughes Medical Institute, New York, NY, USA., Huang EJ; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA., Artyomov M; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA., Glass CK; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Di Paolo G; Denali Therapeutics, Inc., South San Francisco, CA, USA., Ulrich JD; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Holtzman DM; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA. Electronic address: holtzman@wustl.edu. |
| Source: | Cell reports [Cell Rep] 2026 Jan 27; Vol. 45 (1), pp. 116841. Date of Electronic Publication: 2026 Jan 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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