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Personalised multipeptide-based T-cell activator for chronic lymphocytic leukaemia: an open-label, single-centre, phase 1 study.

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Title: Personalised multipeptide-based T-cell activator for chronic lymphocytic leukaemia: an open-label, single-centre, phase 1 study.
Authors: Heitmann JS; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany., Maringer Y; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany., Jung S; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany., Wacker M; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany., Hackenbruch C; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany., Polster M; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Quantitative Biology Center (QBiC), University of Tübingen, Tübingen, Germany; Department of Computer Science, University of Tübingen, Tübingen, Germany., Marconato M; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany., Nelde A; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany., Bauer J; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany., Zwick M; Department of Internal Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, Albert Ludwigs University, Freiburg, Germany; Faculty of Biology, Albert-Ludwigs-Universität, Freiburg, Germany., Baur AS; Department of Internal Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, Albert Ludwigs University, Freiburg, Germany; Faculty of Biology, Albert-Ludwigs-Universität, Freiburg, Germany; CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany; Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany., Metzger A; Faculty of Biology, Albert-Ludwigs-Universität, Freiburg, Germany; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Krolla C; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center-University of Freiburg, Freiburg, Germany., Andrieux G; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Köhler N; Department of Internal Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, Albert Ludwigs University, Freiburg, Germany; CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany., Boerries M; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center-University of Freiburg, Freiburg, Germany., Denk M; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tübingen, partnership between German Cancer Research Center (DKFZ) and University Hospital Tübingen, Tübingen, Germany., Zieschang L; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tübingen, partnership between German Cancer Research Center (DKFZ) and University Hospital Tübingen, Tübingen, Germany., Kammer C; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany., Hoenisch-Gravel N; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany., Richter M; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tübingen, partnership between German Cancer Research Center (DKFZ) and University Hospital Tübingen, Tübingen, Germany., Oezbek MT; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany., Wirths S; Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology, and Rheumatology, University Hospital Tübingen, Tübingen, Germany., Dengler A; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany., Dubbelaar ML; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tübingen, partnership between German Cancer Research Center (DKFZ) and University Hospital Tübingen, Tübingen, Germany; Quantitative Biology Center (QBiC), University of Tübingen, Tübingen, Germany., Pumptow M; Institute for Clinical Epidemiology and Applied Biometry, University Hospital Tübingen, Tübingen, Germany., Martus P; Institute for Clinical Epidemiology and Applied Biometry, University Hospital Tübingen, Tübingen, Germany., Brüggemann M; Department of Hematology and Oncology, University Hospital Schleswig-Holstein Campus, Kiel, Germany., Rammensee HG; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tübingen, partnership between German Cancer Research Center (DKFZ) and University Hospital Tübingen, Tübingen, Germany; Institute of Immunology, University of Tübingen, Tübingen, Germany., Salih HR; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tübingen, partnership between German Cancer Research Center (DKFZ) and University Hospital Tübingen, Tübingen, Germany., Walz JS; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tübingen, partnership between German Cancer Research Center (DKFZ) and University Hospital Tübingen, Tübingen, Germany. Electronic address: juliane.walz@med.uni-tuebingen.de.
Source: The Lancet. Haematology [Lancet Haematol] 2026 Feb; Vol. 13 (2), pp. e74-e85. Date of Electronic Publication: 2026 Jan 14.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101643584 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3026 (Electronic) Linking ISSN: 23523026 NLM ISO Abbreviation: Lancet Haematol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Personalised multipeptide-based T-cell activator for chronic lymphocytic leukaemia: an open-label, single-centre, phase 1 study.
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  Data: <searchLink fieldCode="AU" term="%22Heitmann+JS%22">Heitmann JS</searchLink>; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Maringer+Y%22">Maringer Y</searchLink>; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Jung+S%22">Jung S</searchLink>; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Wacker+M%22">Wacker M</searchLink>; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Hackenbruch+C%22">Hackenbruch C</searchLink>; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Polster+M%22">Polster M</searchLink>; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Quantitative Biology Center (QBiC), University of Tübingen, Tübingen, Germany; Department of Computer Science, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Marconato+M%22">Marconato M</searchLink>; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Nelde+A%22">Nelde A</searchLink>; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Bauer+J%22">Bauer J</searchLink>; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Zwick+M%22">Zwick M</searchLink>; Department of Internal Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, Albert Ludwigs University, Freiburg, Germany; Faculty of Biology, Albert-Ludwigs-Universität, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Baur+AS%22">Baur AS</searchLink>; Department of Internal Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, Albert Ludwigs University, Freiburg, Germany; Faculty of Biology, Albert-Ludwigs-Universität, Freiburg, Germany; CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany; Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Metzger+A%22">Metzger A</searchLink>; Faculty of Biology, Albert-Ludwigs-Universität, Freiburg, Germany; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Krolla+C%22">Krolla C</searchLink>; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center-University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Andrieux+G%22">Andrieux G</searchLink>; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Köhler+N%22">Köhler N</searchLink>; Department of Internal Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, Albert Ludwigs University, Freiburg, Germany; CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Boerries+M%22">Boerries M</searchLink>; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center-University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Denk+M%22">Denk M</searchLink>; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tübingen, partnership between German Cancer Research Center (DKFZ) and University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Zieschang+L%22">Zieschang L</searchLink>; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tübingen, partnership between German Cancer Research Center (DKFZ) and University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kammer+C%22">Kammer C</searchLink>; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Hoenisch-Gravel+N%22">Hoenisch-Gravel N</searchLink>; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Richter+M%22">Richter M</searchLink>; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tübingen, partnership between German Cancer Research Center (DKFZ) and University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Oezbek+MT%22">Oezbek MT</searchLink>; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Wirths+S%22">Wirths S</searchLink>; Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology, and Rheumatology, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Dengler+A%22">Dengler A</searchLink>; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Dubbelaar+ML%22">Dubbelaar ML</searchLink>; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tübingen, partnership between German Cancer Research Center (DKFZ) and University Hospital Tübingen, Tübingen, Germany; Quantitative Biology Center (QBiC), University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Pumptow+M%22">Pumptow M</searchLink>; Institute for Clinical Epidemiology and Applied Biometry, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Martus+P%22">Martus P</searchLink>; Institute for Clinical Epidemiology and Applied Biometry, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Brüggemann+M%22">Brüggemann M</searchLink>; Department of Hematology and Oncology, University Hospital Schleswig-Holstein Campus, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Rammensee+HG%22">Rammensee HG</searchLink>; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tübingen, partnership between German Cancer Research Center (DKFZ) and University Hospital Tübingen, Tübingen, Germany; Institute of Immunology, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Salih+HR%22">Salih HR</searchLink>; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tübingen, partnership between German Cancer Research Center (DKFZ) and University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Walz+JS%22">Walz JS</searchLink>; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180): Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tübingen, partnership between German Cancer Research Center (DKFZ) and University Hospital Tübingen, Tübingen, Germany. Electronic address: juliane.walz@med.uni-tuebingen.de.
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            NameFull: Walz JS
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: 2026 Feb
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2352-3026
          Numbering:
            – Type: volume
              Value: 13
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: The Lancet. Haematology
              Type: main
ResultId 1