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Inhibition of CDK8 rescues impaired ischemic fracture healing.

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Title: Inhibition of CDK8 rescues impaired ischemic fracture healing.
Authors: Capobianco CA; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Song MJ; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Farrell EC; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Knights AJ; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA., Kessell K; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA., Donneys A; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA., Schmanski JT; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Schroeder LR; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Chen M; Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC, USA.; Senex Biotechnology Inc., Columbia, SC, USA., Roninson IB; Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC, USA.; Senex Biotechnology Inc., Columbia, SC, USA., Wagley Y; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA., Maerz T; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA. maerzt@ethz.ch.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. maerzt@ethz.ch.; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. maerzt@ethz.ch.; Institute for Biomechanics, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland. maerzt@ethz.ch., Hankenson KD; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA. kdhank@umich.edu.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. kdhank@umich.edu.; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA. kdhank@umich.edu.
Source: NPJ Regenerative medicine [NPJ Regen Med] 2026 Jan 17; Vol. 11 (1), pp. 12. Date of Electronic Publication: 2026 Jan 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, published in partnership with Monash University and Australian Regenerative Medicine Institute Country of Publication: United States NLM ID: 101699846 Publication Model: Electronic Cited Medium: Internet ISSN: 2057-3995 (Electronic) Linking ISSN: 20573995 NLM ISO Abbreviation: NPJ Regen Med Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Inhibition of CDK8 rescues impaired ischemic fracture healing.
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  Data: <searchLink fieldCode="AU" term="%22Capobianco+CA%22">Capobianco CA</searchLink>; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Song+MJ%22">Song MJ</searchLink>; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Farrell+EC%22">Farrell EC</searchLink>; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Knights+AJ%22">Knights AJ</searchLink>; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Kessell+K%22">Kessell K</searchLink>; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Donneys+A%22">Donneys A</searchLink>; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Schmanski+JT%22">Schmanski JT</searchLink>; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Schroeder+LR%22">Schroeder LR</searchLink>; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink>; Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC, USA.; Senex Biotechnology Inc., Columbia, SC, USA.<br /><searchLink fieldCode="AU" term="%22Roninson+IB%22">Roninson IB</searchLink>; Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC, USA.; Senex Biotechnology Inc., Columbia, SC, USA.<br /><searchLink fieldCode="AU" term="%22Wagley+Y%22">Wagley Y</searchLink>; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Maerz+T%22">Maerz T</searchLink>; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA. maerzt@ethz.ch.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. maerzt@ethz.ch.; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. maerzt@ethz.ch.; Institute for Biomechanics, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland. maerzt@ethz.ch.<br /><searchLink fieldCode="AU" term="%22Hankenson+KD%22">Hankenson KD</searchLink>; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA. kdhank@umich.edu.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. kdhank@umich.edu.; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA. kdhank@umich.edu.
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