A single valine to leucine switch disrupts Plasmodium falciparum AP2-G DNA binding and reveals GDV1's role in ap2-g activation.

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Title: A single valine to leucine switch disrupts Plasmodium falciparum AP2-G DNA binding and reveals GDV1's role in ap2-g activation.
Authors: Prajapati SK; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. surendra.prajapati.ctr@usuhs.edu.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA. surendra.prajapati.ctr@usuhs.edu., Dong JX; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA., Morahan BJ; Laboratory of Malaria and Vector Research, NIAID, NIH, Rockville, MD, USA., Dotrang T; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA., Barbeau MC; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA., Williams AE; Department of Molecular Biology, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.; Integrative Genomics and Bioinformatics Core, The Salk Institute for Biological Studies, La Jolla, CA, USA., Hupalo D; Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Wilkerson MD; Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Dalgard CL; Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Kafsack BFC; Department of Microbiology & Immunology, Weill Cornell Medicine, New York, NY, USA., Llinás M; Department of Biochemistry & Molecular Biology and the Huck Center for Malaria Research, Pennsylvania State University, University Park, PA, USA.; Department of Chemistry, Pennsylvania State University, University Park, PA, USA., Williamson KC; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Source: Nature communications [Nat Commun] 2026 Jan 17; Vol. 17 (1), pp. 1719. Date of Electronic Publication: 2026 Jan 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-68416-1