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A single valine to leucine switch disrupts Plasmodium falciparum AP2-G DNA binding and reveals GDV1's role in ap2-g activation.

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Title: A single valine to leucine switch disrupts Plasmodium falciparum AP2-G DNA binding and reveals GDV1's role in ap2-g activation.
Authors: Prajapati SK; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. surendra.prajapati.ctr@usuhs.edu.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA. surendra.prajapati.ctr@usuhs.edu., Dong JX; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA., Morahan BJ; Laboratory of Malaria and Vector Research, NIAID, NIH, Rockville, MD, USA., Dotrang T; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA., Barbeau MC; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA., Williams AE; Department of Molecular Biology, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.; Integrative Genomics and Bioinformatics Core, The Salk Institute for Biological Studies, La Jolla, CA, USA., Hupalo D; Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Wilkerson MD; Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Dalgard CL; Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Kafsack BFC; Department of Microbiology & Immunology, Weill Cornell Medicine, New York, NY, USA., Llinás M; Department of Biochemistry & Molecular Biology and the Huck Center for Malaria Research, Pennsylvania State University, University Park, PA, USA.; Department of Chemistry, Pennsylvania State University, University Park, PA, USA., Williamson KC; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Source: Nature communications [Nat Commun] 2026 Jan 17; Vol. 17 (1), pp. 1719. Date of Electronic Publication: 2026 Jan 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: A single valine to leucine switch disrupts Plasmodium falciparum AP2-G DNA binding and reveals GDV1's role in ap2-g activation.
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  Data: <searchLink fieldCode="AU" term="%22Prajapati+SK%22">Prajapati SK</searchLink>; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. surendra.prajapati.ctr@usuhs.edu.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA. surendra.prajapati.ctr@usuhs.edu.<br /><searchLink fieldCode="AU" term="%22Dong+JX%22">Dong JX</searchLink>; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Morahan+BJ%22">Morahan BJ</searchLink>; Laboratory of Malaria and Vector Research, NIAID, NIH, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Dotrang+T%22">Dotrang T</searchLink>; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Barbeau+MC%22">Barbeau MC</searchLink>; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Williams+AE%22">Williams AE</searchLink>; Department of Molecular Biology, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.; Integrative Genomics and Bioinformatics Core, The Salk Institute for Biological Studies, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hupalo+D%22">Hupalo D</searchLink>; Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wilkerson+MD%22">Wilkerson MD</searchLink>; Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Dalgard+CL%22">Dalgard CL</searchLink>; Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kafsack+BFC%22">Kafsack BFC</searchLink>; Department of Microbiology & Immunology, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Llinás+M%22">Llinás M</searchLink>; Department of Biochemistry & Molecular Biology and the Huck Center for Malaria Research, Pennsylvania State University, University Park, PA, USA.; Department of Chemistry, Pennsylvania State University, University Park, PA, USA.<br /><searchLink fieldCode="AU" term="%22Williamson+KC%22">Williamson KC</searchLink>; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
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