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EVC protein regulates Sonic hedgehog signaling during human intervertebral disc development and degeneration.

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Title: EVC protein regulates Sonic hedgehog signaling during human intervertebral disc development and degeneration.
Authors: Wu Z; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK., Shaw L; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK., Dube CT; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK.; Manchester Cell-Matrix Centre, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK., Ionescu AM; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK., Qiu T; Centre for Craniofacial & Regenerative Biology, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK., Tierney AL; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK., Baird P; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK., Patel S; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK., Zeef LAH; Bioinformatics Core Facility, Faculty of Biology, Medicine & Health, University of Manchester, Oxford Road, Manchester, UK., Birchall LJ; Division of Diabetes, Endocrinology & Gastroenterology, Faculty of Biology, Medicine & Health, University of Manchester, Oxford Road, Manchester, UK., Jennings RE; Division of Diabetes, Endocrinology & Gastroenterology, Faculty of Biology, Medicine & Health, University of Manchester, Oxford Road, Manchester, UK.; Endocrinology Department, Manchester University NHS Foundation Trust, Manchester, UK., Hanley NA; Division of Diabetes, Endocrinology & Gastroenterology, Faculty of Biology, Medicine & Health, University of Manchester, Oxford Road, Manchester, UK.; College of Medicine & Health, University of Birmingham, Birmingham, UK.; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Unwin RD; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK., Hoyland JA; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK., Richardson SM; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK.; Manchester Cell-Matrix Centre, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK.
Source: IScience [iScience] 2025 Dec 04; Vol. 29 (1), pp. 114290. Date of Electronic Publication: 2025 Dec 04 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
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  Data: EVC protein regulates Sonic hedgehog signaling during human intervertebral disc development and degeneration.
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  Data: <searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Shaw+L%22">Shaw L</searchLink>; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Dube+CT%22">Dube CT</searchLink>; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK.; Manchester Cell-Matrix Centre, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Ionescu+AM%22">Ionescu AM</searchLink>; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Qiu+T%22">Qiu T</searchLink>; Centre for Craniofacial & Regenerative Biology, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Tierney+AL%22">Tierney AL</searchLink>; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Baird+P%22">Baird P</searchLink>; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Patel+S%22">Patel S</searchLink>; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Zeef+LAH%22">Zeef LAH</searchLink>; Bioinformatics Core Facility, Faculty of Biology, Medicine & Health, University of Manchester, Oxford Road, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Birchall+LJ%22">Birchall LJ</searchLink>; Division of Diabetes, Endocrinology & Gastroenterology, Faculty of Biology, Medicine & Health, University of Manchester, Oxford Road, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Jennings+RE%22">Jennings RE</searchLink>; Division of Diabetes, Endocrinology & Gastroenterology, Faculty of Biology, Medicine & Health, University of Manchester, Oxford Road, Manchester, UK.; Endocrinology Department, Manchester University NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Hanley+NA%22">Hanley NA</searchLink>; Division of Diabetes, Endocrinology & Gastroenterology, Faculty of Biology, Medicine & Health, University of Manchester, Oxford Road, Manchester, UK.; College of Medicine & Health, University of Birmingham, Birmingham, UK.; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Unwin+RD%22">Unwin RD</searchLink>; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Hoyland+JA%22">Hoyland JA</searchLink>; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Richardson+SM%22">Richardson SM</searchLink>; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK.; Manchester Cell-Matrix Centre, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK.
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  Data: <searchLink fieldCode="JN" term="%22101724038%22">IScience</searchLink> [iScience] 2025 Dec 04; Vol. 29 (1), pp. 114290. <i>Date of Electronic Publication: </i>2025 Dec 04 (<i>Print Publication: </i>2026).
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