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MCD enzyme deficiency drives early mortality and multiorgan metabolic disruption in Dahl salt-sensitive rats.

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Title: MCD enzyme deficiency drives early mortality and multiorgan metabolic disruption in Dahl salt-sensitive rats.
Authors: Kravtsova O; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA., Tan Y; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark., Levchenko V; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA., Kovalenko E; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark., Tiwari R; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA., Zietara A; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA., Bohovyk R; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA., Dissanayake LV; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA., Van TT; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA., Sharp TE 3rd; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.; Hypertension and Kidney Research Center, University of South Florida, Tampa, FL 33602, USA., Geurts AM; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Palygin O; Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA., Rinschen MM; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.; Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Staruschenko A; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.; Hypertension and Kidney Research Center, University of South Florida, Tampa, FL 33602, USA.; James A. Haley Veteran's Hospital, Tampa, FL 33612, USA.
Source: IScience [iScience] 2025 Dec 19; Vol. 29 (1), pp. 114505. Date of Electronic Publication: 2025 Dec 19 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: MCD enzyme deficiency drives early mortality and multiorgan metabolic disruption in Dahl salt-sensitive rats.
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  Data: <searchLink fieldCode="AU" term="%22Kravtsova+O%22">Kravtsova O</searchLink>; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.<br /><searchLink fieldCode="AU" term="%22Tan+Y%22">Tan Y</searchLink>; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Levchenko+V%22">Levchenko V</searchLink>; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.<br /><searchLink fieldCode="AU" term="%22Kovalenko+E%22">Kovalenko E</searchLink>; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Tiwari+R%22">Tiwari R</searchLink>; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.<br /><searchLink fieldCode="AU" term="%22Zietara+A%22">Zietara A</searchLink>; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.<br /><searchLink fieldCode="AU" term="%22Bohovyk+R%22">Bohovyk R</searchLink>; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.<br /><searchLink fieldCode="AU" term="%22Dissanayake+LV%22">Dissanayake LV</searchLink>; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.<br /><searchLink fieldCode="AU" term="%22Van+TT%22">Van TT</searchLink>; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.<br /><searchLink fieldCode="AU" term="%22Sharp+TE+3rd%22">Sharp TE 3rd</searchLink>; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.; Hypertension and Kidney Research Center, University of South Florida, Tampa, FL 33602, USA.<br /><searchLink fieldCode="AU" term="%22Geurts+AM%22">Geurts AM</searchLink>; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.<br /><searchLink fieldCode="AU" term="%22Palygin+O%22">Palygin O</searchLink>; Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.<br /><searchLink fieldCode="AU" term="%22Rinschen+MM%22">Rinschen MM</searchLink>; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.; Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Staruschenko+A%22">Staruschenko A</searchLink>; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.; Hypertension and Kidney Research Center, University of South Florida, Tampa, FL 33602, USA.; James A. Haley Veteran's Hospital, Tampa, FL 33612, USA.
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  Data: <searchLink fieldCode="JN" term="%22101724038%22">IScience</searchLink> [iScience] 2025 Dec 19; Vol. 29 (1), pp. 114505. <i>Date of Electronic Publication: </i>2025 Dec 19 (<i>Print Publication: </i>2026).
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