Contribution to the Chemotherapy of Human Trypanosomiasis: Design, Synthesis, and Biological Evaluation of Dimeric 2‑Nitroimidazoles against Trypanosoma cruzi Amastigotes and Bloodstream Trypanosoma brucei.
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| Title: | Contribution to the Chemotherapy of Human Trypanosomiasis: Design, Synthesis, and Biological Evaluation of Dimeric 2‑Nitroimidazoles against Trypanosoma cruzi Amastigotes and Bloodstream Trypanosoma brucei. |
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| Authors: | Velez ASMM; Programa de Pós-graduação Em Química, Instituto de Química, Universidade Federal Rural Do Rio de Janeiro, Seropédica, Rio de Janeiro 23.897-000, Brazil., Chaves OA; Department of Chemistry, Coimbra Chemistry Center - Institute of Molecular Science (CQC-IMS), University of Coimbra, Rua Larga, Coimbra 3004-535, Portugal.; Laboratory of Immunopharmacology, Centro de Pesquisa Inovação E Vigilância Em COVID-19 E Emergências Sanitárias (CPIV), Oswaldo Cruz Institute (IOC), Rio de Janeiro, Rio de Janeiro 21040-361, Brazil., Serpa C; Department of Chemistry, Coimbra Chemistry Center - Institute of Molecular Science (CQC-IMS), University of Coimbra, Rua Larga, Coimbra 3004-535, Portugal., Salem FM; Department of Chemistry, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States., Li B; Department of Biology, Geo. & Env. Sciences, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States., Su B; Department of Chemistry, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States., Freire-de-Lima CG; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro 21.941-902, Brazil., Decote-Ricardo D; Departamento de Microbiologia E Imunologia Veterinária, Instituto de Veterinária - Universidade Federal Rural Do Rio de Janeiro, Seropédica, Rio de Janeiro 23897-035, Brazil., Freire de Lima ME; Programa de Pós-graduação Em Química, Instituto de Química, Universidade Federal Rural Do Rio de Janeiro, Seropédica, Rio de Janeiro 23.897-000, Brazil. |
| Source: | ACS omega [ACS Omega] 2025 Dec 26; Vol. 11 (1), pp. 1546-1556. Date of Electronic Publication: 2025 Dec 26 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41552522 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Contribution to the Chemotherapy of Human Trypanosomiasis: Design, Synthesis, and Biological Evaluation of Dimeric 2‑Nitroimidazoles against Trypanosoma cruzi Amastigotes and Bloodstream Trypanosoma brucei. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Velez+ASMM%22">Velez ASMM</searchLink>; Programa de Pós-graduação Em Química, Instituto de Química, Universidade Federal Rural Do Rio de Janeiro, Seropédica, Rio de Janeiro 23.897-000, Brazil.<br /><searchLink fieldCode="AU" term="%22Chaves+OA%22">Chaves OA</searchLink>; Department of Chemistry, Coimbra Chemistry Center - Institute of Molecular Science (CQC-IMS), University of Coimbra, Rua Larga, Coimbra 3004-535, Portugal.; Laboratory of Immunopharmacology, Centro de Pesquisa Inovação E Vigilância Em COVID-19 E Emergências Sanitárias (CPIV), Oswaldo Cruz Institute (IOC), Rio de Janeiro, Rio de Janeiro 21040-361, Brazil.<br /><searchLink fieldCode="AU" term="%22Serpa+C%22">Serpa C</searchLink>; Department of Chemistry, Coimbra Chemistry Center - Institute of Molecular Science (CQC-IMS), University of Coimbra, Rua Larga, Coimbra 3004-535, Portugal.<br /><searchLink fieldCode="AU" term="%22Salem+FM%22">Salem FM</searchLink>; Department of Chemistry, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.<br /><searchLink fieldCode="AU" term="%22Li+B%22">Li B</searchLink>; Department of Biology, Geo. & Env. Sciences, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.<br /><searchLink fieldCode="AU" term="%22Su+B%22">Su B</searchLink>; Department of Chemistry, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.<br /><searchLink fieldCode="AU" term="%22Freire-de-Lima+CG%22">Freire-de-Lima CG</searchLink>; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro 21.941-902, Brazil.<br /><searchLink fieldCode="AU" term="%22Decote-Ricardo+D%22">Decote-Ricardo D</searchLink>; Departamento de Microbiologia E Imunologia Veterinária, Instituto de Veterinária - Universidade Federal Rural Do Rio de Janeiro, Seropédica, Rio de Janeiro 23897-035, Brazil.<br /><searchLink fieldCode="AU" term="%22Freire+de+Lima+ME%22">Freire de Lima ME</searchLink>; Programa de Pós-graduação Em Química, Instituto de Química, Universidade Federal Rural Do Rio de Janeiro, Seropédica, Rio de Janeiro 23.897-000, Brazil. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101691658%22">ACS omega</searchLink> [ACS Omega] 2025 Dec 26; Vol. 11 (1), pp. 1546-1556. <i>Date of Electronic Publication: </i>2025 Dec 26 (<i>Print Publication: </i>2026). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101691658 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2470-1343 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2224701343%22">24701343 </searchLink><i>NLM ISO Abbreviation: </i>ACS Omega <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41552522 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acsomega.5c09284 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1546 Titles: – TitleFull: Contribution to the Chemotherapy of Human Trypanosomiasis: Design, Synthesis, and Biological Evaluation of Dimeric 2‑Nitroimidazoles against Trypanosoma cruzi Amastigotes and Bloodstream Trypanosoma brucei. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Velez ASMM – PersonEntity: Name: NameFull: Chaves OA – PersonEntity: Name: NameFull: Serpa C – PersonEntity: Name: NameFull: Salem FM – PersonEntity: Name: NameFull: Li B – PersonEntity: Name: NameFull: Su B – PersonEntity: Name: NameFull: Freire-de-Lima CG – PersonEntity: Name: NameFull: Decote-Ricardo D – PersonEntity: Name: NameFull: Freire de Lima ME IsPartOfRelationships: – BibEntity: Dates: – D: 26 M: 12 Text: 2025 Dec 26 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2470-1343 Numbering: – Type: volume Value: 11 – Type: issue Value: 1 Titles: – TitleFull: ACS omega Type: main |
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