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A pathogenic titin missense mutation in hiPSC-derived cardiomyocytes predisposes to ventricular fibrillation in acute ST-segment elevation myocardial infarction.

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Title: A pathogenic titin missense mutation in hiPSC-derived cardiomyocytes predisposes to ventricular fibrillation in acute ST-segment elevation myocardial infarction.
Authors: Ji YY; Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China., Wu Y; Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China., Sun J; Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China., Lin XX; Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China., Chen XM; Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China., Ji CC; Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China., Liu LJ; Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China., Cheng YJ; Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China., Wu SH; Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.
Source: Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2026 Jan 02; Vol. 12, pp. 1691585. Date of Electronic Publication: 2026 Jan 02 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101653388 Publication Model: eCollection Cited Medium: Print ISSN: 2297-055X (Print) Linking ISSN: 2297055X NLM ISO Abbreviation: Front Cardiovasc Med Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A pathogenic titin missense mutation in hiPSC-derived cardiomyocytes predisposes to ventricular fibrillation in acute ST-segment elevation myocardial infarction.
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  Data: <searchLink fieldCode="AU" term="%22Ji+YY%22">Ji YY</searchLink>; Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Sun+J%22">Sun J</searchLink>; Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Lin+XX%22">Lin XX</searchLink>; Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+XM%22">Chen XM</searchLink>; Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Ji+CC%22">Ji CC</searchLink>; Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+LJ%22">Liu LJ</searchLink>; Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Cheng+YJ%22">Cheng YJ</searchLink>; Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wu+SH%22">Wu SH</searchLink>; Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.
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  Data: <searchLink fieldCode="JN" term="%22101653388%22">Frontiers in cardiovascular medicine</searchLink> [Front Cardiovasc Med] 2026 Jan 02; Vol. 12, pp. 1691585. <i>Date of Electronic Publication: </i>2026 Jan 02 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media+S%2EA%22">Frontiers Media S.A </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101653388 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2297-055X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222297055X%22">2297055X </searchLink><i>NLM ISO Abbreviation: </i>Front Cardiovasc Med <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41552678
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        Value: 10.3389/fcvm.2025.1691585
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              Text: 2026 Jan 02
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