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No relevant pharmacokinetic interaction between the KRAS G12C inhibitor sotorasib and the direct oral anticoagulant rivaroxaban in healthy subjects.

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Title: No relevant pharmacokinetic interaction between the KRAS G12C inhibitor sotorasib and the direct oral anticoagulant rivaroxaban in healthy subjects.
Authors: Hollander EM; Department of Pharmacy, Pharmacology and Toxicology, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands., Buma AIG; Department of Pulmonology, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands., Leentjens J; Department of Internal Medicine, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands., Janssen PKC; Department of Hospital Pharmacy, VieCuri Medical Center, Venlo, the Netherlands., van den Heuvel MM; Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, the Netherlands., Burger DM; Department of Pharmacy, Pharmacology and Toxicology, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands., Piet B; Department of Pulmonology, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands., Ter Heine R; Department of Pharmacy, Pharmacology and Toxicology, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.
Source: International journal of cancer [Int J Cancer] 2026 Jun 01; Vol. 158 (11), pp. 2920-2927. Date of Electronic Publication: 2026 Jan 19.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: No relevant pharmacokinetic interaction between the KRAS G12C inhibitor sotorasib and the direct oral anticoagulant rivaroxaban in healthy subjects.
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  Data: <searchLink fieldCode="AU" term="%22Hollander+EM%22">Hollander EM</searchLink>; Department of Pharmacy, Pharmacology and Toxicology, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Buma+AIG%22">Buma AIG</searchLink>; Department of Pulmonology, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Leentjens+J%22">Leentjens J</searchLink>; Department of Internal Medicine, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Janssen+PKC%22">Janssen PKC</searchLink>; Department of Hospital Pharmacy, VieCuri Medical Center, Venlo, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Heuvel+MM%22">van den Heuvel MM</searchLink>; Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Burger+DM%22">Burger DM</searchLink>; Department of Pharmacy, Pharmacology and Toxicology, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Piet+B%22">Piet B</searchLink>; Department of Pulmonology, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ter+Heine+R%22">Ter Heine R</searchLink>; Department of Pharmacy, Pharmacology and Toxicology, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.
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  Data: <searchLink fieldCode="JN" term="%220042124%22">International journal of cancer</searchLink> [Int J Cancer] 2026 Jun 01; Vol. 158 (11), pp. 2920-2927. <i>Date of Electronic Publication: </i>2026 Jan 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Liss%22">Wiley-Liss </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0042124 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-0215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200207136%22">00207136 </searchLink><i>NLM ISO Abbreviation: </i>Int J Cancer <i>Subsets: </i>MEDLINE; In Process
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        Value: 10.1002/ijc.70326
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      – TitleFull: No relevant pharmacokinetic interaction between the KRAS G12C inhibitor sotorasib and the direct oral anticoagulant rivaroxaban in healthy subjects.
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              Text: 2026 Jun 01
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