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Upregulation of reward mesolimbic activity and immune response to vaccination: a randomized controlled trial.

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Title: Upregulation of reward mesolimbic activity and immune response to vaccination: a randomized controlled trial.
Authors: Lubianiker N; School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel. nitsan.lubianiker@yale.edu.; Department of Psychology, Yale University, New Haven, CT, USA. nitsan.lubianiker@yale.edu.; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA. nitsan.lubianiker@yale.edu., Koren T; Department of Pathology, Tel Aviv Sourasky Medical Center, in affiliation with the Gray Faculty of Medical and Health Sciences at Tel Aviv University, Tel Aviv, Israel.; School of Neuroscience, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel., Djerasi M; Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Sirotkin M; Department of Pathology, Tel Aviv Sourasky Medical Center, in affiliation with the Gray Faculty of Medical and Health Sciences at Tel Aviv University, Tel Aviv, Israel.; School of Neuroscience, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel., Singer N; Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Jalon I; School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA., Lerner A; Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Sar-El R; Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Sharon H; Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Shahar M; The Tel-Aviv University Center for AI and Data Science, Tel Aviv, Israel., Azulay-Debby H; Department of Pathology, Tel Aviv Sourasky Medical Center, in affiliation with the Gray Faculty of Medical and Health Sciences at Tel Aviv University, Tel Aviv, Israel.; School of Neuroscience, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel., Rolls A; Department of Pathology, Tel Aviv Sourasky Medical Center, in affiliation with the Gray Faculty of Medical and Health Sciences at Tel Aviv University, Tel Aviv, Israel. rolls.asya@gmail.com.; School of Neuroscience, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel. rolls.asya@gmail.com.; Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel. rolls.asya@gmail.com., Hendler T; School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel. talma@tasmc.health.gov.il.; Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. talma@tasmc.health.gov.il.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. talma@tasmc.health.gov.il.; Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel. talma@tasmc.health.gov.il.
Source: Nature medicine [Nat Med] 2026 Feb; Vol. 32 (2), pp. 572-581. Date of Electronic Publication: 2026 Jan 19.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Lubianiker+N%22">Lubianiker N</searchLink>; School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel. nitsan.lubianiker@yale.edu.; Department of Psychology, Yale University, New Haven, CT, USA. nitsan.lubianiker@yale.edu.; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA. nitsan.lubianiker@yale.edu.<br /><searchLink fieldCode="AU" term="%22Koren+T%22">Koren T</searchLink>; Department of Pathology, Tel Aviv Sourasky Medical Center, in affiliation with the Gray Faculty of Medical and Health Sciences at Tel Aviv University, Tel Aviv, Israel.; School of Neuroscience, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Djerasi+M%22">Djerasi M</searchLink>; Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Sirotkin+M%22">Sirotkin M</searchLink>; Department of Pathology, Tel Aviv Sourasky Medical Center, in affiliation with the Gray Faculty of Medical and Health Sciences at Tel Aviv University, Tel Aviv, Israel.; School of Neuroscience, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Singer+N%22">Singer N</searchLink>; Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Jalon+I%22">Jalon I</searchLink>; School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Lerner+A%22">Lerner A</searchLink>; Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Sar-El+R%22">Sar-El R</searchLink>; Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Sharon+H%22">Sharon H</searchLink>; Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Shahar+M%22">Shahar M</searchLink>; The Tel-Aviv University Center for AI and Data Science, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Azulay-Debby+H%22">Azulay-Debby H</searchLink>; Department of Pathology, Tel Aviv Sourasky Medical Center, in affiliation with the Gray Faculty of Medical and Health Sciences at Tel Aviv University, Tel Aviv, Israel.; School of Neuroscience, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Rolls+A%22">Rolls A</searchLink>; Department of Pathology, Tel Aviv Sourasky Medical Center, in affiliation with the Gray Faculty of Medical and Health Sciences at Tel Aviv University, Tel Aviv, Israel. rolls.asya@gmail.com.; School of Neuroscience, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel. rolls.asya@gmail.com.; Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel. rolls.asya@gmail.com.<br /><searchLink fieldCode="AU" term="%22Hendler+T%22">Hendler T</searchLink>; School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel. talma@tasmc.health.gov.il.; Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. talma@tasmc.health.gov.il.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. talma@tasmc.health.gov.il.; Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel. talma@tasmc.health.gov.il.
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