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GDF-15 Levels in Cirrhosis Are Linked to Hepatic Fibrogenesis, Bacterial Translocation, and Worse Clinical Outcomes.

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Title: GDF-15 Levels in Cirrhosis Are Linked to Hepatic Fibrogenesis, Bacterial Translocation, and Worse Clinical Outcomes.
Authors: Hofer BS; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Christian Doppler Lab for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria., Perkmann T; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria., Brusilovskaya K; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Christian Doppler Lab for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, Vienna, Austria.; Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria., Balcar L; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria., Hintersteininger M; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria., Kramer G; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria., Simbrunner B; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Christian Doppler Lab for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria.; Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria., Caparros E; CIBEREHD, Instituto de Salud Carlos III, Madrid, Spain.; Department of Clinical Medicine, Hepatic and Intestinal Immunobiology Group, Miguel Hernández University, Elche, Spain.; Instituto IDIBE, Miguel Hernández University, Elche, Spain., Francés R; CIBEREHD, Instituto de Salud Carlos III, Madrid, Spain.; Department of Clinical Medicine, Hepatic and Intestinal Immunobiology Group, Miguel Hernández University, Elche, Spain.; Instituto IDIBE, Miguel Hernández University, Elche, Spain.; Instituto ISABIAL, Hospital General Universitario de Alicante, Alicante, Spain., Eichelberger B; Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria., Lee S; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria., Zinober K; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Christian Doppler Lab for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, Vienna, Austria., Bödendorfer B; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria., Radovanovic-Petrova B; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria., Thöne P; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria., Sebesta C; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria., Jachs M; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria., Hartl L; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria., Schwabl P; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Christian Doppler Lab for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria.; Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria., Mandorfer M; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria., Panzer S; Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria., Reiberger T; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Christian Doppler Lab for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria.; Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria., Gremmel T; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.; Institute of Cardiovascular Pharmacotherapy and Interventional Cardiology, Karl Landsteiner Society, St. Pölten, Austria.; Department of Internal Medicine I, Cardiology and Intensive Care Medicine, Landesklinikum Mistelbach-Gänserndorf, Mistelbach, Austria.; Karl Landsteiner University of Health Sciences, Krems, Austria.
Source: Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2026 Feb; Vol. 46 (2), pp. e70516.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101160857 Publication Model: Print Cited Medium: Internet ISSN: 1478-3231 (Electronic) Linking ISSN: 14783223 NLM ISO Abbreviation: Liver Int Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: GDF-15 Levels in Cirrhosis Are Linked to Hepatic Fibrogenesis, Bacterial Translocation, and Worse Clinical Outcomes.
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  Data: <searchLink fieldCode="AU" term="%22Hofer+BS%22">Hofer BS</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Christian Doppler Lab for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Perkmann+T%22">Perkmann T</searchLink>; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Brusilovskaya+K%22">Brusilovskaya K</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Christian Doppler Lab for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, Vienna, Austria.; Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Balcar+L%22">Balcar L</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Hintersteininger+M%22">Hintersteininger M</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Kramer+G%22">Kramer G</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Simbrunner+B%22">Simbrunner B</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Christian Doppler Lab for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria.; Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Caparros+E%22">Caparros E</searchLink>; CIBEREHD, Instituto de Salud Carlos III, Madrid, Spain.; Department of Clinical Medicine, Hepatic and Intestinal Immunobiology Group, Miguel Hernández University, Elche, Spain.; Instituto IDIBE, Miguel Hernández University, Elche, Spain.<br /><searchLink fieldCode="AU" term="%22Francés+R%22">Francés R</searchLink>; CIBEREHD, Instituto de Salud Carlos III, Madrid, Spain.; Department of Clinical Medicine, Hepatic and Intestinal Immunobiology Group, Miguel Hernández University, Elche, Spain.; Instituto IDIBE, Miguel Hernández University, Elche, Spain.; Instituto ISABIAL, Hospital General Universitario de Alicante, Alicante, Spain.<br /><searchLink fieldCode="AU" term="%22Eichelberger+B%22">Eichelberger B</searchLink>; Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Lee+S%22">Lee S</searchLink>; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Zinober+K%22">Zinober K</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Christian Doppler Lab for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Bödendorfer+B%22">Bödendorfer B</searchLink>; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Radovanovic-Petrova+B%22">Radovanovic-Petrova B</searchLink>; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Thöne+P%22">Thöne P</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Sebesta+C%22">Sebesta C</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Jachs+M%22">Jachs M</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Hartl+L%22">Hartl L</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Schwabl+P%22">Schwabl P</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Christian Doppler Lab for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria.; Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Mandorfer+M%22">Mandorfer M</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Panzer+S%22">Panzer S</searchLink>; Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Reiberger+T%22">Reiberger T</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria.; Christian Doppler Lab for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, Vienna, Austria.; Clinical Research Group (CRG) MOTION, Medical University of Vienna, Vienna, Austria.; Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Gremmel+T%22">Gremmel T</searchLink>; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.; Institute of Cardiovascular Pharmacotherapy and Interventional Cardiology, Karl Landsteiner Society, St. Pölten, Austria.; Department of Internal Medicine I, Cardiology and Intensive Care Medicine, Landesklinikum Mistelbach-Gänserndorf, Mistelbach, Austria.; Karl Landsteiner University of Health Sciences, Krems, Austria.
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