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Tetravalent antibodies are more potent and efficacious erythropoiesis-stimulating agents than erythropoietin in vivo.

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Title: Tetravalent antibodies are more potent and efficacious erythropoiesis-stimulating agents than erythropoietin in vivo.
Authors: Adams JJ; Anvil Institute for Systems Biologics, Toronto, Ontario, Canada.; EPOK Therapeutics, Toronto, Ontario, Canada.; Simisco Biosciences, Hayward, California, USA., Blazer LL; Anvil Institute for Systems Biologics, Toronto, Ontario, Canada., Chung J; Anvil Institute for Systems Biologics, Toronto, Ontario, Canada.; EPOK Therapeutics, Toronto, Ontario, Canada., Karimi M; Département de Biochimie, Université de Montréal, Montréal, Québec, Canada., Davidson T; Departments of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Blair B; Departments of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Waddle C; Departments of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Hokanson CA; Simisco Biosciences, Hayward, California, USA., Bruce HA; Anvil Institute for Systems Biologics, Toronto, Ontario, Canada., Singer AU; Anvil Institute for Systems Biologics, Toronto, Ontario, Canada., Tombak EM; Icosagen, Tartu, Estonia., Gildemann K; Icosagen, Tartu, Estonia., Tamberg N; Icosagen, Tartu, Estonia., Kiiver K; Icosagen, Tartu, Estonia., Ustav M Jr; Icosagen, Tartu, Estonia., Ma Y; Departments of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Colombo L; EPOK Therapeutics, Toronto, Ontario, Canada., Huang LJ; Departments of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Michnick SW; Département de Biochimie, Université de Montréal, Montréal, Québec, Canada., Moe OW; EPOK Therapeutics, Toronto, Ontario, Canada.; Departments of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Sidhu SS; Anvil Institute for Systems Biologics, Toronto, Ontario, Canada.; EPOK Therapeutics, Toronto, Ontario, Canada.; Simisco Biosciences, Hayward, California, USA.
Source: Protein science : a publication of the Protein Society [Protein Sci] 2026 Feb; Vol. 35 (2), pp. e70462.
Publication Type: Journal Article
Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tetravalent antibodies are more potent and efficacious erythropoiesis-stimulating agents than erythropoietin in vivo.
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  Data: <searchLink fieldCode="AU" term="%22Adams+JJ%22">Adams JJ</searchLink>; Anvil Institute for Systems Biologics, Toronto, Ontario, Canada.; EPOK Therapeutics, Toronto, Ontario, Canada.; Simisco Biosciences, Hayward, California, USA.<br /><searchLink fieldCode="AU" term="%22Blazer+LL%22">Blazer LL</searchLink>; Anvil Institute for Systems Biologics, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Chung+J%22">Chung J</searchLink>; Anvil Institute for Systems Biologics, Toronto, Ontario, Canada.; EPOK Therapeutics, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Karimi+M%22">Karimi M</searchLink>; Département de Biochimie, Université de Montréal, Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Davidson+T%22">Davidson T</searchLink>; Departments of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Blair+B%22">Blair B</searchLink>; Departments of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Waddle+C%22">Waddle C</searchLink>; Departments of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Hokanson+CA%22">Hokanson CA</searchLink>; Simisco Biosciences, Hayward, California, USA.<br /><searchLink fieldCode="AU" term="%22Bruce+HA%22">Bruce HA</searchLink>; Anvil Institute for Systems Biologics, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Singer+AU%22">Singer AU</searchLink>; Anvil Institute for Systems Biologics, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Tombak+EM%22">Tombak EM</searchLink>; Icosagen, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Gildemann+K%22">Gildemann K</searchLink>; Icosagen, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Tamberg+N%22">Tamberg N</searchLink>; Icosagen, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Kiiver+K%22">Kiiver K</searchLink>; Icosagen, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Ustav+M+Jr%22">Ustav M Jr</searchLink>; Icosagen, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; Departments of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Colombo+L%22">Colombo L</searchLink>; EPOK Therapeutics, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Huang+LJ%22">Huang LJ</searchLink>; Departments of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Michnick+SW%22">Michnick SW</searchLink>; Département de Biochimie, Université de Montréal, Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Moe+OW%22">Moe OW</searchLink>; EPOK Therapeutics, Toronto, Ontario, Canada.; Departments of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Sidhu+SS%22">Sidhu SS</searchLink>; Anvil Institute for Systems Biologics, Toronto, Ontario, Canada.; EPOK Therapeutics, Toronto, Ontario, Canada.; Simisco Biosciences, Hayward, California, USA.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cold+Spring+Harbor+Laboratory+Press%22">Cold Spring Harbor Laboratory Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9211750 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1469-896X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209618368%22">09618368 </searchLink><i>NLM ISO Abbreviation: </i>Protein Sci <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb
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