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KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment.

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Title: KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment.
Authors: Burge RA; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina., Le Roux O; Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina., Popow O; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Brigham & Women's Hospital, and Harvard Medical School, Boston, Massachusetts., Spadafora VK; Department of Pediatrics, Darby Children's Research Institute, Medical University of South Carolina, Charleston, South Carolina., Rajesh C; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina., Adair SJ; Department of Surgery, University of Virginia, Charlottesville, Virginia., Bialousow L; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina., Murphy C; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina., Saberi S; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina., Vaena SG; Bioinformatics Core, Medical University of South Carolina, Charleston, South Carolina., Taquey MC; College of Graduate Studies, Medical University of South Carolina, Charleston, South Carolina., Allen S; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina., Han L; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina., Helke KL; Department of Comparative Medicine, Medical University of South Carolina, Charleston, South Carolina., Sharma S; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina., Ostrowski MC; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina., Guttridge DC; Department of Pediatrics, Darby Children's Research Institute, Medical University of South Carolina, Charleston, South Carolina.; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina., Dincman TA; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.; Division of Hematology and Oncology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina., Bauer TW; Department of Surgery, University of Virginia, Charlottesville, Virginia., Kashatus DF; Department Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia., McFall T; Department of Biochemistry and MCW Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin., Haigis KM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Brigham & Women's Hospital, and Harvard Medical School, Boston, Massachusetts., Hollingsworth MA; Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska., Counter CM; Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina., Der CJ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Hobbs GA; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Source: Cancer research [Cancer Res] 2026 Apr 15; Vol. 86 (8), pp. 1868-1882.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
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Department of Surgery, University of Virginia, Charlottesville, Virginia.<br /><searchLink fieldCode="AU" term="%22Bialousow+L%22">Bialousow L</searchLink>; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.<br /><searchLink fieldCode="AU" term="%22Murphy+C%22">Murphy C</searchLink>; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.<br /><searchLink fieldCode="AU" term="%22Saberi+S%22">Saberi S</searchLink>; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.<br /><searchLink fieldCode="AU" term="%22Vaena+SG%22">Vaena SG</searchLink>; Bioinformatics Core, Medical University of South Carolina, Charleston, South Carolina.<br /><searchLink fieldCode="AU" term="%22Taquey+MC%22">Taquey MC</searchLink>; College of Graduate Studies, Medical University of South Carolina, Charleston, South Carolina.<br /><searchLink fieldCode="AU" term="%22Allen+S%22">Allen S</searchLink>; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.<br /><searchLink fieldCode="AU" term="%22Han+L%22">Han L</searchLink>; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.<br /><searchLink fieldCode="AU" term="%22Helke+KL%22">Helke KL</searchLink>; Department of Comparative Medicine, Medical University of South Carolina, Charleston, South Carolina.<br /><searchLink fieldCode="AU" term="%22Sharma+S%22">Sharma S</searchLink>; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.<br /><searchLink fieldCode="AU" term="%22Ostrowski+MC%22">Ostrowski MC</searchLink>; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.<br /><searchLink fieldCode="AU" term="%22Guttridge+DC%22">Guttridge DC</searchLink>; Department of Pediatrics, Darby Children's Research Institute, Medical University of South Carolina, Charleston, South Carolina.; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.<br /><searchLink fieldCode="AU" term="%22Dincman+TA%22">Dincman TA</searchLink>; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.; Division of Hematology and Oncology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.<br /><searchLink fieldCode="AU" term="%22Bauer+TW%22">Bauer TW</searchLink>; Department of Surgery, University of Virginia, Charlottesville, Virginia.<br /><searchLink fieldCode="AU" term="%22Kashatus+DF%22">Kashatus DF</searchLink>; Department Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia.<br /><searchLink fieldCode="AU" term="%22McFall+T%22">McFall T</searchLink>; Department of Biochemistry and MCW Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Haigis+KM%22">Haigis KM</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Brigham & Women's Hospital, and Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Hollingsworth+MA%22">Hollingsworth MA</searchLink>; Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska.<br /><searchLink fieldCode="AU" term="%22Counter+CM%22">Counter CM</searchLink>; Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina.<br /><searchLink fieldCode="AU" term="%22Der+CJ%22">Der CJ</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Hobbs+GA%22">Hobbs GA</searchLink>; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
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