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Oxyphenbutazone improves memory and learning impairments in LPS-induced neurotoxicity via modulating TGF-β/NF-κB/IκB-α pathways: In silico and in vivo study.

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Title: Oxyphenbutazone improves memory and learning impairments in LPS-induced neurotoxicity via modulating TGF-β/NF-κB/IκB-α pathways: In silico and in vivo study.
Authors: Alharbi KS; Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Al Qassim 51452, Saudi Arabia., Afzal M; Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia., Alenezi SK; Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Al Qassim 51452, Saudi Arabia., ALQahtani R; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdul Rahman University, Riyadh, KSA., Alsahli TG; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72341, Saudi Arabia., Imam F; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, 11452, P.O. Box 145111, Saudi Arabia., Kazmi I; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Source: PloS one [PLoS One] 2026 Jan 20; Vol. 21 (1), pp. e0337611. Date of Electronic Publication: 2026 Jan 20 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Oxyphenbutazone improves memory and learning impairments in LPS-induced neurotoxicity via modulating TGF-β/NF-κB/IκB-α pathways: In silico and in vivo study.
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  Data: <searchLink fieldCode="AU" term="%22Alharbi+KS%22">Alharbi KS</searchLink>; Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Al Qassim 51452, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Afzal+M%22">Afzal M</searchLink>; Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alenezi+SK%22">Alenezi SK</searchLink>; Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Al Qassim 51452, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22ALQahtani+R%22">ALQahtani R</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdul Rahman University, Riyadh, KSA.<br /><searchLink fieldCode="AU" term="%22Alsahli+TG%22">Alsahli TG</searchLink>; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72341, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Imam+F%22">Imam F</searchLink>; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, 11452, P.O. Box 145111, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Kazmi+I%22">Kazmi I</searchLink>; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2026 Jan 20; Vol. 21 (1), pp. e0337611. <i>Date of Electronic Publication: </i>2026 Jan 20 (<i>Print Publication: </i>2026).
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      – TitleFull: Oxyphenbutazone improves memory and learning impairments in LPS-induced neurotoxicity via modulating TGF-β/NF-κB/IκB-α pathways: In silico and in vivo study.
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