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Medium-Chain Fatty Acid Receptor GPR84 Modulates Cytotoxic CD8 T-cell Antitumor Immunity through Metabolic Reprogramming.

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Title: Medium-Chain Fatty Acid Receptor GPR84 Modulates Cytotoxic CD8 T-cell Antitumor Immunity through Metabolic Reprogramming.
Authors: Philbrook P; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana., Dean MJ; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana., Sanchez-Pino MD; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana., Zheng LQ; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana., Zabaleta J; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana., Vázquez-Martínez JA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Chang D; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Mandula JK; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Shaw TI; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Wyczechowska D; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana., Garai J; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana., Thylur Puttalingaiah R; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana., Mansouri A; Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana., Huang W; School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana., Das S; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Chang S; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Conejo-Garcia JR; Department of Integrated Immunobiology, Duke School of Medicine, Durham, North Carolina., Rodriguez PC; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Ochoa AC; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
Source: Cancer immunology research [Cancer Immunol Res] 2026 Apr 02; Vol. 14 (4), pp. 640-657.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101614637 Publication Model: Print Cited Medium: Internet ISSN: 2326-6074 (Electronic) Linking ISSN: 23266066 NLM ISO Abbreviation: Cancer Immunol Res Subsets: MEDLINE
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  Data: Medium-Chain Fatty Acid Receptor GPR84 Modulates Cytotoxic CD8 T-cell Antitumor Immunity through Metabolic Reprogramming.
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  Data: <searchLink fieldCode="AU" term="%22Philbrook+P%22">Philbrook P</searchLink>; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.<br /><searchLink fieldCode="AU" term="%22Dean+MJ%22">Dean MJ</searchLink>; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.<br /><searchLink fieldCode="AU" term="%22Sanchez-Pino+MD%22">Sanchez-Pino MD</searchLink>; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.<br /><searchLink fieldCode="AU" term="%22Zheng+LQ%22">Zheng LQ</searchLink>; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.<br /><searchLink fieldCode="AU" term="%22Zabaleta+J%22">Zabaleta J</searchLink>; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana.<br /><searchLink fieldCode="AU" term="%22Vázquez-Martínez+JA%22">Vázquez-Martínez JA</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Chang+D%22">Chang D</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Mandula+JK%22">Mandula JK</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Shaw+TI%22">Shaw TI</searchLink>; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Wyczechowska+D%22">Wyczechowska D</searchLink>; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.<br /><searchLink fieldCode="AU" term="%22Garai+J%22">Garai J</searchLink>; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.<br /><searchLink fieldCode="AU" term="%22Thylur+Puttalingaiah+R%22">Thylur Puttalingaiah R</searchLink>; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.<br /><searchLink fieldCode="AU" term="%22Mansouri+A%22">Mansouri A</searchLink>; Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.<br /><searchLink fieldCode="AU" term="%22Huang+W%22">Huang W</searchLink>; School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana.<br /><searchLink fieldCode="AU" term="%22Das+S%22">Das S</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Chang+S%22">Chang S</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Conejo-Garcia+JR%22">Conejo-Garcia JR</searchLink>; Department of Integrated Immunobiology, Duke School of Medicine, Durham, North Carolina.<br /><searchLink fieldCode="AU" term="%22Rodriguez+PC%22">Rodriguez PC</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Ochoa+AC%22">Ochoa AC</searchLink>; LSU LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.; Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
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