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Targeting mechanosensitive cannabinoid receptor 1 with isoflavone prodrugs attenuates atherosclerotic endothelial dysfunction.

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Title: Targeting mechanosensitive cannabinoid receptor 1 with isoflavone prodrugs attenuates atherosclerotic endothelial dysfunction.
Authors: Chung DJ; Department and Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, 1st Section, Taipei, 10051, Taiwan., Chen SP; Department and Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, 1st Section, Taipei, 10051, Taiwan., Liu WH; Department and Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, 1st Section, Taipei, 10051, Taiwan., Liu CY; Department and Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, 1st Section, Taipei, 10051, Taiwan., Su NW; Department of Agricultural Chemistry, National Taiwan University, Taipei, 106319, Taiwan.; Department of Biochemical Science and Technology, National Taiwan University, Taipei, 106319, Taiwan., Hsu C; Department of Agricultural Chemistry, National Taiwan University, Taipei, 106319, Taiwan., Tsai HY; Department of Agricultural Chemistry, National Taiwan University, Taipei, 106319, Taiwan., Yang KC; Department and Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, 1st Section, Taipei, 10051, Taiwan.; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, 100225, Taiwan., Wu CK; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, 100225, Taiwan., Lin SW; Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan., Shie JJ; Institute of Chemistry, Academia Sinica, 128 Academia Road, Section 2, Taipei, 11529, Taiwan., Zhao MT; Center for Cardiovascular Research, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, 43210, USA.; The Heart Center, Nationwide Children's Hospital, Columbus, OH, 43210, USA.; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA., Wei TT; Department and Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, 1st Section, Taipei, 10051, Taiwan. ttwei@ntu.edu.tw.; Chemical Biology and Molecular Biophysics, Taiwan International Graduate Program in Chemical Biology and Molecular Biophysics (TIGP-CBMB), Academia Sinica, Taipei, 11529, Taiwan. ttwei@ntu.edu.tw.
Source: Journal of biomedical science [J Biomed Sci] 2026 Jan 21; Vol. 33 (1), pp. 12. Date of Electronic Publication: 2026 Jan 21.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9421567 Publication Model: Electronic Cited Medium: Internet ISSN: 1423-0127 (Electronic) Linking ISSN: 10217770 NLM ISO Abbreviation: J Biomed Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting mechanosensitive cannabinoid receptor 1 with isoflavone prodrugs attenuates atherosclerotic endothelial dysfunction.
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  Data: <searchLink fieldCode="AU" term="%22Chung+DJ%22">Chung DJ</searchLink>; Department and Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, 1st Section, Taipei, 10051, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+SP%22">Chen SP</searchLink>; Department and Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, 1st Section, Taipei, 10051, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+WH%22">Liu WH</searchLink>; Department and Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, 1st Section, Taipei, 10051, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+CY%22">Liu CY</searchLink>; Department and Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, 1st Section, Taipei, 10051, Taiwan.<br /><searchLink fieldCode="AU" term="%22Su+NW%22">Su NW</searchLink>; Department of Agricultural Chemistry, National Taiwan University, Taipei, 106319, Taiwan.; Department of Biochemical Science and Technology, National Taiwan University, Taipei, 106319, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+C%22">Hsu C</searchLink>; Department of Agricultural Chemistry, National Taiwan University, Taipei, 106319, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+HY%22">Tsai HY</searchLink>; Department of Agricultural Chemistry, National Taiwan University, Taipei, 106319, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+KC%22">Yang KC</searchLink>; Department and Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, 1st Section, Taipei, 10051, Taiwan.; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, 100225, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+CK%22">Wu CK</searchLink>; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, 100225, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+SW%22">Lin SW</searchLink>; Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shie+JJ%22">Shie JJ</searchLink>; Institute of Chemistry, Academia Sinica, 128 Academia Road, Section 2, Taipei, 11529, Taiwan.<br /><searchLink fieldCode="AU" term="%22Zhao+MT%22">Zhao MT</searchLink>; Center for Cardiovascular Research, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, 43210, USA.; The Heart Center, Nationwide Children's Hospital, Columbus, OH, 43210, USA.; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.<br /><searchLink fieldCode="AU" term="%22Wei+TT%22">Wei TT</searchLink>; Department and Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, 1st Section, Taipei, 10051, Taiwan. ttwei@ntu.edu.tw.; Chemical Biology and Molecular Biophysics, Taiwan International Graduate Program in Chemical Biology and Molecular Biophysics (TIGP-CBMB), Academia Sinica, Taipei, 11529, Taiwan. ttwei@ntu.edu.tw.
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              Text: 2026 Jan 21
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