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Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review.

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Title: Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review.
Authors: Aegerter H; Center for Inflammation Research, Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium., Brightling CE; Institute for Lung Health, National Institute for Health and Care Research, Leicester Biomedical Research Centre, University of Leicester, Leicester, UK. ceb17@leicester.ac.uk., Dunican EM; School of Medicine, University College Dublin, Dublin, Ireland., Lambrecht BN; Center for Inflammation Research, Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium., Lugogo NL; Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA., Newell JD Jr; Department of Radiology, University of Iowa, Iowa City, IA, USA., Porsbjerg C; Department of Respiratory Medicine and Infectious Diseases, Bispebjerg Hospital, Copenhagen University, Copenhagen, Denmark., Svenningsen S; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.; Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, ON, Canada., Clarke D; Respiratory and Immunology, BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK., Lindsley AW; US Medical Affairs, Amgen, Thousand Oaks, CA, USA., Nordenmark L; Late-stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Oslo, Norway., Ambrose CS; Respiratory and Immunology, BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, USA., Castro M; Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, University of Kansas, Kansas City, KS, USA.
Source: Respiratory research [Respir Res] 2026 Jan 21; Vol. 27 (1), pp. 69. Date of Electronic Publication: 2026 Jan 21.
Publication Type: Systematic Review; Journal Article; Review
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Aegerter+H%22">Aegerter H</searchLink>; Center for Inflammation Research, Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Brightling+CE%22">Brightling CE</searchLink>; Institute for Lung Health, National Institute for Health and Care Research, Leicester Biomedical Research Centre, University of Leicester, Leicester, UK. ceb17@leicester.ac.uk.<br /><searchLink fieldCode="AU" term="%22Dunican+EM%22">Dunican EM</searchLink>; School of Medicine, University College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Lambrecht+BN%22">Lambrecht BN</searchLink>; Center for Inflammation Research, Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Lugogo+NL%22">Lugogo NL</searchLink>; Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Newell+JD+Jr%22">Newell JD Jr</searchLink>; Department of Radiology, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Porsbjerg+C%22">Porsbjerg C</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Bispebjerg Hospital, Copenhagen University, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Svenningsen+S%22">Svenningsen S</searchLink>; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.; Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Clarke+D%22">Clarke D</searchLink>; Respiratory and Immunology, BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lindsley+AW%22">Lindsley AW</searchLink>; US Medical Affairs, Amgen, Thousand Oaks, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nordenmark+L%22">Nordenmark L</searchLink>; Late-stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Ambrose+CS%22">Ambrose CS</searchLink>; Respiratory and Immunology, BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Castro+M%22">Castro M</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, University of Kansas, Kansas City, KS, USA.
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  Data: <searchLink fieldCode="JN" term="%22101090633%22">Respiratory research</searchLink> [Respir Res] 2026 Jan 21; Vol. 27 (1), pp. 69. <i>Date of Electronic Publication: </i>2026 Jan 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central+Ltd%22">BioMed Central Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101090633 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1465-993X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214659921%22">14659921 </searchLink><i>NLM ISO Abbreviation: </i>Respir Res <i>Subsets: </i>MEDLINE
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