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Overexpression of bank vole PrP(I109) in mice induces a spontaneous atypical prion disease with sex-dependent onset, early NfL elevation, and universal prion strain permissiveness.

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Title: Overexpression of bank vole PrP(I109) in mice induces a spontaneous atypical prion disease with sex-dependent onset, early NfL elevation, and universal prion strain permissiveness.
Authors: Eraña H; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain.; ATLAS Molecular Pharma S. L., Derio, Spain., Vidal E; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de La Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain., Fernández-Borges N; Centro de Investigación en Sanidad Animal (CISA), Consejo Superior de Investigaciones Científicas (CSIC), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Valdeolmos, Madrid, Spain., Charco JM; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain.; ATLAS Molecular Pharma S. L., Derio, Spain., Díaz-Domínguez CM; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Sampedro-Torres-Quevedo C; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain., San-Juan-Ansoleaga M; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Fernández-Muñoz E; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Galarza-Ahumada J; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Pérez-Castro MÁ; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Gonçalves-Anjo N; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Piñeiro P; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Pirisinu L; Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanita, Rome, Italy., Di Bari MA; Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanita, Rome, Italy., Giler S; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de La Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain., Raimondi I; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Espinosa JC; Centro de Investigación en Sanidad Animal (CISA), Consejo Superior de Investigaciones Científicas (CSIC), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Valdeolmos, Madrid, Spain., Vanni I; Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanita, Rome, Italy., D'Agostino C; Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanita, Rome, Italy., Rodríguez-Cuesta J; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Pasetto L; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Bonetto V; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., González-Martín N; Institute for Biomedical Research of Salamanca (IBSAL), University Hospital of Salamanca, University of Salamanca, Spanish National Research Council (CSIC), Salamanca, Spain., Teijeira S; Grupo de Enfermedades Raras y Medicina Pediátrica, Instituto de Investigación Sanitaria Galicia Sur (IISGS), Vigo, Spain., Zou WQ; Institute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China., Geijo M; Animal Health Department, NEIKER-Basque Institute for Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), Derio, Spain., Torres JM; Centro de Investigación en Sanidad Animal (CISA), Consejo Superior de Investigaciones Científicas (CSIC), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Valdeolmos, Madrid, Spain., Chiesa R; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Sánchez-Martín MA; Institute for Biomedical Research of Salamanca (IBSAL), University Hospital of Salamanca, University of Salamanca, Spanish National Research Council (CSIC), Salamanca, Spain.; Transgenic Facility, Department of Medicine, University of Salamanca, 37007, Salamanca, Spain., Nonno R; Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanita, Rome, Italy., Requena JR; CIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Santiago, Spain., Castilla J; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain. jcastilla@cicbiogune.es.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain. jcastilla@cicbiogune.es.; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain. jcastilla@cicbiogune.es.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2026 Jan 20; Vol. 14 (1), pp. 40. Date of Electronic Publication: 2026 Jan 20.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Overexpression of bank vole PrP(I109) in mice induces a spontaneous atypical prion disease with sex-dependent onset, early NfL elevation, and universal prion strain permissiveness.
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  Data: <searchLink fieldCode="AU" term="%22Eraña+H%22">Eraña H</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain.; ATLAS Molecular Pharma S. L., Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Vidal+E%22">Vidal E</searchLink>; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de La Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández-Borges+N%22">Fernández-Borges N</searchLink>; Centro de Investigación en Sanidad Animal (CISA), Consejo Superior de Investigaciones Científicas (CSIC), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Valdeolmos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Charco+JM%22">Charco JM</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain.; ATLAS Molecular Pharma S. L., Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Díaz-Domínguez+CM%22">Díaz-Domínguez CM</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Sampedro-Torres-Quevedo+C%22">Sampedro-Torres-Quevedo C</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22San-Juan-Ansoleaga+M%22">San-Juan-Ansoleaga M</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández-Muñoz+E%22">Fernández-Muñoz E</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Galarza-Ahumada+J%22">Galarza-Ahumada J</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Pérez-Castro+MÁ%22">Pérez-Castro MÁ</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Gonçalves-Anjo+N%22">Gonçalves-Anjo N</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Piñeiro+P%22">Piñeiro P</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Pirisinu+L%22">Pirisinu L</searchLink>; Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanita, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Bari+MA%22">Di Bari MA</searchLink>; Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanita, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Giler+S%22">Giler S</searchLink>; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de La Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Raimondi+I%22">Raimondi I</searchLink>; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Espinosa+JC%22">Espinosa JC</searchLink>; Centro de Investigación en Sanidad Animal (CISA), Consejo Superior de Investigaciones Científicas (CSIC), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Valdeolmos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Vanni+I%22">Vanni I</searchLink>; Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanita, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22D'Agostino+C%22">D'Agostino C</searchLink>; Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanita, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Cuesta+J%22">Rodríguez-Cuesta J</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Pasetto+L%22">Pasetto L</searchLink>; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bonetto+V%22">Bonetto V</searchLink>; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22González-Martín+N%22">González-Martín N</searchLink>; Institute for Biomedical Research of Salamanca (IBSAL), University Hospital of Salamanca, University of Salamanca, Spanish National Research Council (CSIC), Salamanca, Spain.<br /><searchLink fieldCode="AU" term="%22Teijeira+S%22">Teijeira S</searchLink>; Grupo de Enfermedades Raras y Medicina Pediátrica, Instituto de Investigación Sanitaria Galicia Sur (IISGS), Vigo, Spain.<br /><searchLink fieldCode="AU" term="%22Zou+WQ%22">Zou WQ</searchLink>; Institute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.<br /><searchLink fieldCode="AU" term="%22Geijo+M%22">Geijo M</searchLink>; Animal Health Department, NEIKER-Basque Institute for Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Torres+JM%22">Torres JM</searchLink>; Centro de Investigación en Sanidad Animal (CISA), Consejo Superior de Investigaciones Científicas (CSIC), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Valdeolmos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Chiesa+R%22">Chiesa R</searchLink>; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Sánchez-Martín+MA%22">Sánchez-Martín MA</searchLink>; Institute for Biomedical Research of Salamanca (IBSAL), University Hospital of Salamanca, University of Salamanca, Spanish National Research Council (CSIC), Salamanca, Spain.; Transgenic Facility, Department of Medicine, University of Salamanca, 37007, Salamanca, Spain.<br /><searchLink fieldCode="AU" term="%22Nonno+R%22">Nonno R</searchLink>; Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanita, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Requena+JR%22">Requena JR</searchLink>; CIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Santiago, Spain.<br /><searchLink fieldCode="AU" term="%22Castilla+J%22">Castilla J</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain. jcastilla@cicbiogune.es.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain. jcastilla@cicbiogune.es.; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain. jcastilla@cicbiogune.es.
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