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Understanding dopaminergic dose reduction following STN-DBS: mediation analysis.

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Title: Understanding dopaminergic dose reduction following STN-DBS: mediation analysis.
Authors: Lanore A; Department of Neurology, CIC Neurosciences, Pitié-Salpêtrière University Hospital, Paris, France., Houot M; Department of Neurology, CIC Neurosciences, Pitié-Salpêtrière University Hospital, Paris, Île-de-France, France., Basset A; Institut du Cerveau-Paris Brain Institute-ICM, Sorbonne Université, Paris, France., Bendetowicz D; Institut du Cerveau-Paris Brain Institute-ICM, Sorbonne Université, Paris, France., Menon PJ; Institut du Cerveau-Paris Brain Institute-ICM, Sorbonne Université, Paris, France., Bardinet E; Institut du Cerveau-Paris Brain Institute-ICM, Sorbonne Université, Paris, France., Fernandez Vidal S; Paris Brain Institute, Paris, Île-de-France, France., Cornillault J; Institut du Cerveau-Paris Brain Institute-ICM, Sorbonne Université, Paris, France., Karachi C; Institut du Cerveau-Paris Brain Institute-ICM, Sorbonne Université, Paris, France., Navarro S; Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, Paris, France., Ihle J; Institut du Cerveau-Paris Brain Institute-ICM, Sorbonne Université, Paris, France., Eusebio A; APHM, Marseille, France., Giordana C; Department of Neurology, Centre Hospitalier Universitaire de Nice, Nice, Provence-Alpes-Côte d'Azu, France., Rouaud T; Department of Neurology, Nantes University Hospital, Nantes, France., Drapier S; Neurologie, CHU Pontchaillou, Rennes, France., Guehl D; Pôle de Neurosciences Cliniques, CHU de Bordeaux, Bordeaux, France.; CNRS UMR 5293, Institut des Maladies Neurodegeneratives, Bordeaux, France., Marques A; EA7280, Université Clermont Auvergne, Clermont-Ferrand, France.; Neurology, University Hospital Centre Clermont-Ferrand, Clermont-Ferrand, France., Hubsch C; Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France., Jarraya B; Neuroscience, Hospital Foch, Suresnes, Île-de-France, France., Benatru I; Centre Hospitalier Universitaire de Poitiers, Poitiers, France., Thobois S; Neurology C, Hopital Neurologique Pierre Wertheimer, Lyon, France., Hopes L; Neurology, Centre Hospitalier Universitaire de Nancy, Nancy, Lorraine, France., Maltete D; Neurology, Rouen University Hospital, Rouen, France., Rascol O; Pharmacology, Toulouse University, Toulouse, France., Tir M; Amiens University Hospital, Amiens, France., Moreau C; Department of Medical Pharmacology, University Hospital Lille, Lille, France., Tranchant C; Neurologie, Hopital de Hautepierre, Strasbourg, France., Rolland AS; Department of Medical Pharmacology, Neurology and Movement Disorders Department, Referent center of Parkinson's disease, CHU of Lille, Univ. Lille Neuroscience & Cognition, Inserm, UMR-S1172, Lille, France., Devos D; Medical Pharmacology, Lille University Medical Center, Lille, France., Corvol JC; Department of Neurology, CIC Neurosciences, Pitié-Salpêtrière University Hospital, Paris, France., Grabli D; Department of Neurology, Pitié-Salpêtrière University Hospital, Paris, France., Hainque E; Department of Neurology, Pitié-Salpêtrière University Hospital, Paris, France.
Corporate Authors: PREDISTIM study group
Source: BMJ neurology open [BMJ Neurol Open] 2026 Jan 16; Vol. 8 (1), pp. e001427. Date of Electronic Publication: 2026 Jan 16 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: British Medical Association Country of Publication: England NLM ID: 101775450 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-6140 (Electronic) Linking ISSN: 26326140 NLM ISO Abbreviation: BMJ Neurol Open Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Lanore+A%22">Lanore A</searchLink>; Department of Neurology, CIC Neurosciences, Pitié-Salpêtrière University Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Houot+M%22">Houot M</searchLink>; Department of Neurology, CIC Neurosciences, Pitié-Salpêtrière University Hospital, Paris, Île-de-France, France.<br /><searchLink fieldCode="AU" term="%22Basset+A%22">Basset A</searchLink>; Institut du Cerveau-Paris Brain Institute-ICM, Sorbonne Université, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bendetowicz+D%22">Bendetowicz D</searchLink>; Institut du Cerveau-Paris Brain Institute-ICM, Sorbonne Université, Paris, France.<br /><searchLink fieldCode="AU" term="%22Menon+PJ%22">Menon PJ</searchLink>; Institut du Cerveau-Paris Brain Institute-ICM, Sorbonne Université, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bardinet+E%22">Bardinet E</searchLink>; Institut du Cerveau-Paris Brain Institute-ICM, Sorbonne Université, Paris, France.<br /><searchLink fieldCode="AU" term="%22Fernandez+Vidal+S%22">Fernandez Vidal S</searchLink>; Paris Brain Institute, Paris, Île-de-France, France.<br /><searchLink fieldCode="AU" term="%22Cornillault+J%22">Cornillault J</searchLink>; Institut du Cerveau-Paris Brain Institute-ICM, Sorbonne Université, Paris, France.<br /><searchLink fieldCode="AU" term="%22Karachi+C%22">Karachi C</searchLink>; Institut du Cerveau-Paris Brain Institute-ICM, Sorbonne Université, Paris, France.<br /><searchLink fieldCode="AU" term="%22Navarro+S%22">Navarro S</searchLink>; Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ihle+J%22">Ihle J</searchLink>; Institut du Cerveau-Paris Brain Institute-ICM, Sorbonne Université, Paris, France.<br /><searchLink fieldCode="AU" term="%22Eusebio+A%22">Eusebio A</searchLink>; APHM, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Giordana+C%22">Giordana C</searchLink>; Department of Neurology, Centre Hospitalier Universitaire de Nice, Nice, Provence-Alpes-Côte d'Azu, France.<br /><searchLink fieldCode="AU" term="%22Rouaud+T%22">Rouaud T</searchLink>; Department of Neurology, Nantes University Hospital, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Drapier+S%22">Drapier S</searchLink>; Neurologie, CHU Pontchaillou, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Guehl+D%22">Guehl D</searchLink>; Pôle de Neurosciences Cliniques, CHU de Bordeaux, Bordeaux, France.; CNRS UMR 5293, Institut des Maladies Neurodegeneratives, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Marques+A%22">Marques A</searchLink>; EA7280, Université Clermont Auvergne, Clermont-Ferrand, France.; Neurology, University Hospital Centre Clermont-Ferrand, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Hubsch+C%22">Hubsch C</searchLink>; Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.<br /><searchLink fieldCode="AU" term="%22Jarraya+B%22">Jarraya B</searchLink>; Neuroscience, Hospital Foch, Suresnes, Île-de-France, France.<br /><searchLink fieldCode="AU" term="%22Benatru+I%22">Benatru I</searchLink>; Centre Hospitalier Universitaire de Poitiers, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Thobois+S%22">Thobois S</searchLink>; Neurology C, Hopital Neurologique Pierre Wertheimer, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Hopes+L%22">Hopes L</searchLink>; Neurology, Centre Hospitalier Universitaire de Nancy, Nancy, Lorraine, France.<br /><searchLink fieldCode="AU" term="%22Maltete+D%22">Maltete D</searchLink>; Neurology, Rouen University Hospital, Rouen, France.<br /><searchLink fieldCode="AU" term="%22Rascol+O%22">Rascol O</searchLink>; Pharmacology, Toulouse University, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Tir+M%22">Tir M</searchLink>; Amiens University Hospital, Amiens, France.<br /><searchLink fieldCode="AU" term="%22Moreau+C%22">Moreau C</searchLink>; Department of Medical Pharmacology, University Hospital Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Tranchant+C%22">Tranchant C</searchLink>; Neurologie, Hopital de Hautepierre, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Rolland+AS%22">Rolland AS</searchLink>; Department of Medical Pharmacology, Neurology and Movement Disorders Department, Referent center of Parkinson's disease, CHU of Lille, Univ. Lille Neuroscience & Cognition, Inserm, UMR-S1172, Lille, France.<br /><searchLink fieldCode="AU" term="%22Devos+D%22">Devos D</searchLink>; Medical Pharmacology, Lille University Medical Center, Lille, France.<br /><searchLink fieldCode="AU" term="%22Corvol+JC%22">Corvol JC</searchLink>; Department of Neurology, CIC Neurosciences, Pitié-Salpêtrière University Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Grabli+D%22">Grabli D</searchLink>; Department of Neurology, Pitié-Salpêtrière University Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Hainque+E%22">Hainque E</searchLink>; Department of Neurology, Pitié-Salpêtrière University Hospital, Paris, France.
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