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Second attempt to discontinue TKI after molecular relapse in patients with chronic myeloid leukemia: A real-life Italian multicenter study.

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Title: Second attempt to discontinue TKI after molecular relapse in patients with chronic myeloid leukemia: A real-life Italian multicenter study.
Authors: Iurlo A; Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy., Cattaneo D; Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy., Fava C; Department of Clinical and Biological Sciences, University of Turin, Mauriziano Hospital, Torino, Italy., Castagnetti F; Institute of Hematology 'Seràgnoli', IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Bonifacio M; Department of Medicine, Section of Hematology, University of Verona, Verona, Italy., D'Adda M; Hematology Unit, ASST Spedali Civili, Brescia, Italy., Miggiano MC; Division of Hematology, San Bortolo Hospital, Vicenza, Italy., Capodanno I; Hematology Unit, Azienda Unità Sanitaria Locale-IRCCS, Reggio Emilia, Italy., Elena C; Unit of Molecular Hematology & Precision Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Levato L; Hematology Unit, Ospedale di Catanzaro, Catanzaro, Italy., Scortechini AR; Clinica di Ematologia, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy., Lunghi F; Department of Onco-Hematology - Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute and Vita-Salute Hospital, Milano, Italy., Caramella M; Division of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy., Orofino N; Division of Hematology, Hospital Legnano-Milan, Legnano, Italy., Maffioli M; Hematology Unit, ASST Sette Laghi, Ospedale di Circolo, Varese, Italy., Bellani V; Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy., Bonuomo V; Department of Clinical and Biological Sciences, University of Turin, Mauriziano Hospital, Torino, Italy., Grano S; Department of Clinical and Biological Sciences, University of Turin, Mauriziano Hospital, Torino, Italy., Cotilli G; Hematology Department, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Scalzulli E; Hematology Unit, Department of Precision and Translational Medicine, Policlinico Umberto 1, Sapienza University, Roma, Italy., Dalmazzo M; Division of Hematology and Internal Medicine, 'San Luigi Gonzaga' University Hospital, Orbassano, Italy., Crescenzi SL; Hematology Unit, San Giovanni Hospital, Roma, Italy., Luciano L; Division of Hematology, Department of Clinical Medicine and Surgery, Federico II University, Napoli, Italy., Martino B; Hematology Unit, Grande Ospedale Metropolitano-G.O.M. Bianchi-Melacrino-Morelli, Reggio Calabria, Italy., Intermesoli T; Hematology and Bone Marrow Transplant Unit, ASST Ospedale Papa Giovanni XXIII, Bergamo, Italy., Rapezzi D; Hematology Unit, Ospedale di Cuneo, Cuneo, Italy., Binotto G; Department of Medicine, Hematology and Clinical Immunology, Padua School of Medicine, Padova, Italy., Tiribelli M; Division of Hematology and BMT, Department of Medical and Morphological Research, University of Udine, Udine, Italy., Consonni D; Occupational Health Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy., Pane F; Division of Hematology, Department of Clinical Medicine and Surgery, Federico II University, Napoli, Italy., Saglio G; Department of Clinical and Biological Sciences, University of Turin, Torino, Italy., Gambacorti-Passerini C; Hematology Department, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Breccia M; Hematology Unit, Department of Precision and Translational Medicine, Policlinico Umberto 1, Sapienza University, Roma, Italy., Rosti G; Department of Hematology, Istituto Amadori, Meldola, Italy.
Source: Cancer [Cancer] 2026 Feb 01; Vol. 132 (3), pp. e70261.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0374236 Publication Model: Print Cited Medium: Internet ISSN: 1097-0142 (Electronic) Linking ISSN: 0008543X NLM ISO Abbreviation: Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Second attempt to discontinue TKI after molecular relapse in patients with chronic myeloid leukemia: A real-life Italian multicenter study.
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  Data: <searchLink fieldCode="AU" term="%22Iurlo+A%22">Iurlo A</searchLink>; Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Cattaneo+D%22">Cattaneo D</searchLink>; Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Fava+C%22">Fava C</searchLink>; Department of Clinical and Biological Sciences, University of Turin, Mauriziano Hospital, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Castagnetti+F%22">Castagnetti F</searchLink>; Institute of Hematology 'Seràgnoli', IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Bonifacio+M%22">Bonifacio M</searchLink>; Department of Medicine, Section of Hematology, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22D'Adda+M%22">D'Adda M</searchLink>; Hematology Unit, ASST Spedali Civili, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Miggiano+MC%22">Miggiano MC</searchLink>; Division of Hematology, San Bortolo Hospital, Vicenza, Italy.<br /><searchLink fieldCode="AU" term="%22Capodanno+I%22">Capodanno I</searchLink>; Hematology Unit, Azienda Unità Sanitaria Locale-IRCCS, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Elena+C%22">Elena C</searchLink>; Unit of Molecular Hematology & Precision Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Levato+L%22">Levato L</searchLink>; Hematology Unit, Ospedale di Catanzaro, Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Scortechini+AR%22">Scortechini AR</searchLink>; Clinica di Ematologia, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Lunghi+F%22">Lunghi F</searchLink>; Department of Onco-Hematology - Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute and Vita-Salute Hospital, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Caramella+M%22">Caramella M</searchLink>; Division of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Orofino+N%22">Orofino N</searchLink>; Division of Hematology, Hospital Legnano-Milan, Legnano, Italy.<br /><searchLink fieldCode="AU" term="%22Maffioli+M%22">Maffioli M</searchLink>; Hematology Unit, ASST Sette Laghi, Ospedale di Circolo, Varese, Italy.<br /><searchLink fieldCode="AU" term="%22Bellani+V%22">Bellani V</searchLink>; Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Bonuomo+V%22">Bonuomo V</searchLink>; Department of Clinical and Biological Sciences, University of Turin, Mauriziano Hospital, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Grano+S%22">Grano S</searchLink>; Department of Clinical and Biological Sciences, University of Turin, Mauriziano Hospital, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Cotilli+G%22">Cotilli G</searchLink>; Hematology Department, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Scalzulli+E%22">Scalzulli E</searchLink>; Hematology Unit, Department of Precision and Translational Medicine, Policlinico Umberto 1, Sapienza University, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Dalmazzo+M%22">Dalmazzo M</searchLink>; Division of Hematology and Internal Medicine, 'San Luigi Gonzaga' University Hospital, Orbassano, Italy.<br /><searchLink fieldCode="AU" term="%22Crescenzi+SL%22">Crescenzi SL</searchLink>; Hematology Unit, San Giovanni Hospital, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Luciano+L%22">Luciano L</searchLink>; Division of Hematology, Department of Clinical Medicine and Surgery, Federico II University, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Martino+B%22">Martino B</searchLink>; Hematology Unit, Grande Ospedale Metropolitano-G.O.M. Bianchi-Melacrino-Morelli, Reggio Calabria, Italy.<br /><searchLink fieldCode="AU" term="%22Intermesoli+T%22">Intermesoli T</searchLink>; Hematology and Bone Marrow Transplant Unit, ASST Ospedale Papa Giovanni XXIII, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Rapezzi+D%22">Rapezzi D</searchLink>; Hematology Unit, Ospedale di Cuneo, Cuneo, Italy.<br /><searchLink fieldCode="AU" term="%22Binotto+G%22">Binotto G</searchLink>; Department of Medicine, Hematology and Clinical Immunology, Padua School of Medicine, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Tiribelli+M%22">Tiribelli M</searchLink>; Division of Hematology and BMT, Department of Medical and Morphological Research, University of Udine, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Consonni+D%22">Consonni D</searchLink>; Occupational Health Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Pane+F%22">Pane F</searchLink>; Division of Hematology, Department of Clinical Medicine and Surgery, Federico II University, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Saglio+G%22">Saglio G</searchLink>; Department of Clinical and Biological Sciences, University of Turin, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Gambacorti-Passerini+C%22">Gambacorti-Passerini C</searchLink>; Hematology Department, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Breccia+M%22">Breccia M</searchLink>; Hematology Unit, Department of Precision and Translational Medicine, Policlinico Umberto 1, Sapienza University, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Rosti+G%22">Rosti G</searchLink>; Department of Hematology, Istituto Amadori, Meldola, Italy.
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  Data: <searchLink fieldCode="JN" term="%220374236%22">Cancer</searchLink> [Cancer] 2026 Feb 01; Vol. 132 (3), pp. e70261.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0374236 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-0142 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220008543X%22">0008543X </searchLink><i>NLM ISO Abbreviation: </i>Cancer <i>Subsets: </i>MEDLINE
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