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A Ciliary Phosphoinositide Pathway Regulates the Dosage of Polycystins in Primary Cilia.

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Title: A Ciliary Phosphoinositide Pathway Regulates the Dosage of Polycystins in Primary Cilia.
Authors: Chen C; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota., Wang Z; Department of Biological Sciences, St. John's University, New York, New York., Gao Y; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota., Ellis MR; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota., Ji B; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota., Sieben CJ; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota., Haycraft CJ; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Croyle M; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Aghevli A; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota., Xu Q; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota., Robichaud JH; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota., He K; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota., Chen C; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota., Huang Y; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota., Yoder BK; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Hu J; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota., Harris PC; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota., Yu Y; Department of Biological Sciences, St. John's University, New York, New York., Ling K; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Source: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2026 May 01; Vol. 37 (5), pp. 944-958. Date of Electronic Publication: 2025 Nov 25.
Publication Type: Journal Article
Journal Info: Publisher: Wolters Kluwer Health, on behalf of the American Society of Nephrology Country of Publication: United States NLM ID: 9013836 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-3450 (Electronic) Linking ISSN: 10466673 NLM ISO Abbreviation: J Am Soc Nephrol Subsets: MEDLINE
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  Data: A Ciliary Phosphoinositide Pathway Regulates the Dosage of Polycystins in Primary Cilia.
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  Data: <searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Biological Sciences, St. John's University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Ellis+MR%22">Ellis MR</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Ji+B%22">Ji B</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Sieben+CJ%22">Sieben CJ</searchLink>; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Haycraft+CJ%22">Haycraft CJ</searchLink>; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.<br /><searchLink fieldCode="AU" term="%22Croyle+M%22">Croyle M</searchLink>; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.<br /><searchLink fieldCode="AU" term="%22Aghevli+A%22">Aghevli A</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Xu+Q%22">Xu Q</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Robichaud+JH%22">Robichaud JH</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22He+K%22">He K</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Yoder+BK%22">Yoder BK</searchLink>; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.<br /><searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Harris+PC%22">Harris PC</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Yu+Y%22">Yu Y</searchLink>; Department of Biological Sciences, St. John's University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Ling+K%22">Ling K</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
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  Data: <searchLink fieldCode="JN" term="%229013836%22">Journal of the American Society of Nephrology : JASN</searchLink> [J Am Soc Nephrol] 2026 May 01; Vol. 37 (5), pp. 944-958. <i>Date of Electronic Publication: </i>2025 Nov 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wolters+Kluwer+Health%2C+on+behalf+of+the+American+Society+of+Nephrology%22">Wolters Kluwer Health, on behalf of the American Society of Nephrology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9013836 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1533-3450 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210466673%22">10466673 </searchLink><i>NLM ISO Abbreviation: </i>J Am Soc Nephrol <i>Subsets: </i>MEDLINE
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